Table 3: Features of common spontaneous and transgenic mouse models for SjS.

CharacteristicAutoantibodiesSjögren’s syndrome patientSpontaneous mouse modelTransgenic mouse model
NODAec1Aec2NZB/
W F1
MRL/
lpr
NFS/
sld
IQI/
Jic
Aly/
aly
HTLV-1BAFFIL-6IL-10IL-12IL-14α

Anti-Ro/SS-A, Anti-La/SS-BYesYesNoNoYesYesNoNoNoYesYes
Anti-DNA (ANAs)YesYesYesYesYesYesYesYesYes
Anti-α-fodrinYesYesYesYes
Anti-β-adrenergic receptorYesYesYesYesYes
Anti-type3 muscarinic Ach receptorYesYesYesYesYes

Leukocytic infiltrateYesYesYesYesYesYesYesYesYesYesYesYesYesYes
 - Time of onset (weeks)121016816824245228<1648
DacryoadenitisYesYesYesYesYesYesYesYesYesYes
SialadenitisYesYesYesYesYesYesYesYesYesYesYesYesYes
Loss secretory functionYesVarYesVarNoYesYesYesVarVar
 - Time of onset (weeks)201924725281612
 - Target organS, LS, LLS, LSS, LS, LS
Proinflammatory cytokine productYesYesYesYesYesYesYesYesYesYesYes

Var: variable, male, and female mice differ, –: Not determined, S: Salivary glands, L: Lacrimal glands.