Current Concepts: Mouse Models of Sjögren's Syndrome

Table 4

Features of common knockout, immunization, infection, and transplantation chimera mouse models for SjS.

Characteristic	Autoantibodies	Sjögren’s syndrome patient	Knockout (KO) mouse model					Immunization mouse model		Infectionmouse model	Transplantation chimeras
			Id3	PI3K	TGF-β1	TSP-1	Ar	CAII	Ro	CMV	GVHR
	Anti-Ro/SS-A, Anti-La/SS-B	Yes	Yes	Yes	No	Yes	—	—	Yes	Yes	—
	Anti-DNA (ANAs)	Yes	—	—	Yes	—	No	—	—	—	Yes
	Anti-α-fodrin	Yes	—	—	—	—	Yes	—	—	—	—
	Anti-β-adrenergic receptor	Yes	—	—	—	—	—	—	—	—	—
	Anti-type3 muscarinic Ach receptor	Yes	—	—	—	—	—	—	—	—	—
Leukocytic infiltrate		Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
- Time of onset (weeks)			8	8	1	24	48	—	16	4	28
Dacryoadenitis		Yes	Yes	Yes	—	Yes	—	Yes	—	—	—
Sialadenitis		Yes	Yes	Yes	Yes	—	Yes	Yes	Yes	Yes	Yes
Loss of secretory function		Yes	Yes	Yes	Yes	Yes	—	—	Yes	Yes	—
- Time of onset (weeks)			8	<8	>1	24	—	—	16	4	—
- Target organ			S, L	S, L	S	L	—	—	S	S	—
Proinflammatory cytokine product		Yes	—	Yes	Yes	Yes	—	—	—	—	—

Var: variable, male, and female mice differ, –: Not determined, S: Salivary glands, L: Lacrimal glands.