Feasibility of Treating Irradiated Bone with Intramedullary Delivered Autologous Mesenchymal Stem Cells

Table 2

Post-therapeutic value of ^99mTc-HDP bone uptake of the irradiated hindlimbs. Results were expressed as relative to the unirradiated hindlimb.

		Hindlimb	posttherapeutic 48 H	posttherapeutic 168 H	posttherapeutic 2 months
Bone blood flow	Knee	Irradiated untreated	−0.40±1.30	−0.76±1.62	+0.16±0.91
		Irradiated treated	−0.30±0.89	−1.18±0.87	+0.20±0.98
	Tibia	Irradiated untreated	+0.95±1.43	+0.21±1.45	−0.01±0.49
		Irradiated treated	+2.00±0.68 *	+0.70±1.03 *	+0.40±0.53
	Foot	Irradiated untreated	+1.05±1.12	+0.26±1.57	+0.46±0.31
		Irradiated treated	+1.64±1.25	+1.02±0.96	+0.56±0.90
Bone osteoblastic metabolism	Knee	Irradiated untreated	−2.12±1.25	−1.06±1.06	−1.21±1.13
		Irradiated treated	−1.68±1.43	−1.57±1.44	−1.16±0.98
	Tibia	Irradiated untreated	+0.28±0.85	−0.04±0.67	−0.01±0.66
		Irradiated treated	+0.77±0.56 *	+0.47±0.58 *	+0.07±0.56
	Foot	Irradiated untreated	+0.36±0.89	+0.01±1.19	+0.07±0.59
		Irradiated treated	+1.07±1.21	+0.58±0.62	+0.43±0.96

* 𝑃<0.05  versus contralateral nonirradiated legs.