Jun Dimerization Protein 2 Controls Senescence and Differentiation via Regulating Histone Modification
Figure 3
Proposed model of the epigenetic regulation of the expression of the genes for p16Ink4a and Arf by JDP2. The exposure of young MEF primary cells to aging stress leads to the accumulation of JDP2. JDP2 binds to histones and inhibits the methylation of H3K27 at the p16Ink4a/Arf locus. As a result, PRC-1 and PRC-2 fail to form stable repressive complexes and are released from the locus. The consequent expression of p16Ink4a and Arf in the aged cells leads to growth arrest and senescence stage.
