Rodent Preclinical Models for Developing Novel Antiarthritic Molecules: Comparative Biology and Preferred Methods for Evaluating Efficacy

Table 2

Initiation of major induced rat models of immune-mediated arthritis commonly used in preclinical development.

Model	Inciting agents	Adjuvant	Strain	Gender	Inoculation route	Day of disease onset	Incidence	Group size
Adjuvant- induced arthritis (AIA-Myc)	Mycobacterium tuberculosis H37Ra (heat-killed)	Paraffin oil	Lewis	Male	Intradermal (once at the tail base)	9	100%	6 or more
Collagen-induced arthritis (CIA)	Type II collagen (porcine)	Incomplete Freund's adjuvant	Lewis	Female	Intradermal (10 sites over the back)	9 to 11	80% up to 100%	8 or more
Streptococcal cell wall-induced arthritis (SCW)	Cell wall peptidoglycan-polysaccharide (PG-PS 100P) from Streptococcus pyogenes, Group A, strain D58	Phosphate-buffered saline	Lewis	Female	Intra-articular (induction); intravenous (reactivation)	29 or 30 (reactivated)	90% up to 100%	8 or more