569628.fig.001
Figure 1: The sarcomeric Z-disc—multiple functions and links to maladaptation. The figure links various functions and structural aspects to maladaptation and disease, such as mutations in Z-disc proteins which are linked to different diseases. Defects in mechanosensation and mechanotransduction are linked to Z-disc mediated autophagy and UPS which in turn are linked to skeletal and cardiac muscle disease.