- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 571784, 9 pages
Variability in Estrogen-Metabolizing Genes and Their Association with Genomic Instability in Untreated Breast Cancer Patients and Healthy Women
1Department of Genetics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Bloco G., Avenue Bandeirantes, 3900, 14049-900 Ribeirão Preto, SP, Brazil
2Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
3Department of Biology, Faculty of Philosophy, Sciences and Letters of Ribeirão, University of São Paulo, 14040-901 Ribeirão Preto, SP, Brazil
Received 17 February 2011; Accepted 17 April 2011
Academic Editor: Manoor Prakash Hande
Copyright © 2011 Raquel Alves dos Santos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- B. S. Hulka and P. G. Moorman, “Breast cancer: hormones and other risk factors,” Maturitas, vol. 38, no. 1, pp. 103–116, 2001.
- V. N. Kristensen and A. L. Borresen-Dale, “Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism,” Mutation Research, vol. 462, no. 2-3, pp. 323–333, 2000.
- H. J. Kang, S. W. Kim, H. J. Kim et al., “Polymorphisms in the estrogen receptor-alpha gene and breast cancer risk,” Cancer Letters, vol. 178, no. 2, pp. 175–180, 2002.
- K. Mitrunen and A. Hirvonen, “Molecular epidemiology of sporadic breast cancer: the role of polymorphic genes involved in oestrogen biosynthesis and metabolism,” Mutation Research, vol. 544, no. 1, pp. 9–41, 2003.
- A. M. Dunning, C. S. Healey, P. D. P. Pharoah, M. D. Teare, B. A. J. Ponder, and D. F. Easton, “A systematic review of genetic polymorphisms and breast cancer risk,” Cancer Epidemiology Biomarkers and Prevention, vol. 8, no. 10, pp. 843–854, 1999.
- J. D. Yager and N. E. Davidson, “Estrogen carcinogenesis in breast cancer,” New England Journal of Medicine, vol. 354, no. 3, pp. 228–282, 2006.
- N. R. Bianco, G. Perry, M. A. Smith, D. J. Templeton, and M. M. Montano, “Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage,” Molecular Endocrinology, vol. 17, no. 7, pp. 1344–1355, 2003.
- D. Roy and J. G. Liehr, “Estrogen, DNA damage and mutations,” Mutation Research, vol. 424, no. 1-2, pp. 107–115, 1999.
- X. Yuan, G. Zhou, Y. Zhai et al., “Lack of association between the functional polymorphisms in the estrogen-metabolizing genes and risk for hepatocellular carcinoma,” Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 12, pp. 3621–3627, 1999.
- M. Fenech and A. A. Morley, “Measurement of micronuclei in lymphocytes,” Mutation Research, vol. 147, no. 1-2, pp. 29–36, 1985.
- M. Fenech, “The in vitro micronucleus technique,” Mutation Research, vol. 455, no. 1-2, pp. 81–95, 2000.
- T. J. Key, N. E. Allen, E. A. Spencer, and R. C. Travis, “The effect of diet on risk of cancer,” Lancet, vol. 360, no. 9336, pp. 861–868, 2002.
- B. Zumoff, “Does postmenopausal estrogen administration increase the risk of breast cancer? Contributions of animal, biochemical, and clinical investigative studies to a resolution of the controversy,” Proceedings of the Society for Experimental Biology and Medicine, vol. 217, no. 1, pp. 30–37, 1998.
- J. Lou, J. He, W. Zheng et al., “Investigating the genetic instability in the peripheral lymphocytes of 36 untreated lung cancer patients with comet assay and micronucleus assay,” Mutation Research, vol. 617, no. 1-2, pp. 104–110, 2007.
- C. Bolognesi, C. Lando, A. Forni et al., “Chromosomal damage and ageing: effect on micronuclei frequency in peripheral blood lymphocytes,” Age and Ageing, vol. 28, no. 4, pp. 393–397, 1999.
- D. Varga, J. Hoegel, C. Maier et al., “On the difference of micronucleus frequencies in peripheral blood lymphocytes between breast cancer patients and controls,” Mutagenesis, vol. 21, no. 5, pp. 313–320, 2006.
- S. Pastor, A. Creus, T. Parrón et al., “Biomonitoring of four European populations occupationally exposed to pesticides: use of micronuclei as biomarkers,” Mutagenesis, vol. 18, no. 3, pp. 249–258, 2003.
- M. B. Schabath, M. R. Spitz, H. B. Grossman et al., “Genetic instability in bladder cancer assessed by the comet assay,” Journal of the National Cancer Institute, vol. 95, no. 7, pp. 540–547, 2003.
- Z. Hamurcu, H. Dönmez-Altuntas, and T. Patiroglu, “Basal level micronucleus frequency in stimulated lymphocytes of untreated patients with leukemia,” Cancer Genetics and Cytogenetics, vol. 180, no. 2, pp. 140–144, 2008.
- L. Sharp, A. H. Cardy, S. C. Cotton, and J. Little, “CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. A HuGE review,” American Journal of Epidemiology, vol. 160, no. 8, pp. 729–740, 2004.
- P. E. Abrahamson, S. S. Tworoger, E. J. Aiello et al., “Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors,” Breast Cancer Research and Treatment, vol. 105, no. 1, pp. 45–54, 2007.
- Y. Chen and J. Pei, “Factors influencing the association between CYP17 T34C polymorphism and the risk of breast cancer: meta-regression and subgroup analysis,” Breast Cancer Research and Treatment, vol. 122, no. 2, pp. 471–481, 2010.
- L. R. Bailey, N. Roodi, W. D. Dupont, and F. F. Parl, “Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer,” Cancer Research, vol. 58, no. 22, pp. 5038–5041, 1998.
- W. Zheng, D. W. Xie, F. Jin et al., “Genetic polymorphism of cytochrome P450-1B1 and risk of breast cancer,” Cancer Epidemiology Biomarkers and Prevention, vol. 9, no. 2, pp. 147–150, 2000.
- N. A. Kocabas, S. Sardas, S. Cholerton, A. K. Daly, and A. E. Karakaya, “Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population,” Archives of Toxicology, vol. 76, no. 11, pp. 643–649, 2002.
- V. Paracchini, S. Raimondi, I. T. Gram et al., “Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review,” American Journal of Epidemiology, vol. 165, no. 2, pp. 115–125, 2007.
- B. T. Zhu and A. H. Conney, “Functional role of estrogen metabolism in target cells: Review and perspectives,” Carcinogenesis, vol. 19, no. 1, pp. 1–27, 1998.
- Y. Miyoshi and S. Noguchi, “Polymorphisms of estrogen synthesizing and metabolizing genes and breast cancer risk in Japanese women,” Biomedicine and Pharmacotherapy, vol. 57, no. 10, pp. 471–481, 2003.
- C. Chen, Y. Huang, Y. Li, Y. Mao, and Y. Xie, “Cytochrome P450 1A1 (CYP1A1) T3801C and A2455G polymorphisms in breast cancer risk: a meta-analysis,” Journal of Human Genetics, vol. 52, no. 5, pp. 423–435, 2007.
- E. Taioli, H. L. Bradlow, S. V. Garbers et al., “Role of estradiol metabolism and CYP1A1 polymorphisms in breast cancer risk,” Cancer Detection and Prevention, vol. 23, no. 3, pp. 232–237, 1999.
- C. S. Huang, H. D. Chern, K. J. Chang, C. W. Cheng, S. M. Hsu, and C. Y. Shen, “Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: A multigenic study on cancer susceptibility,” Cancer Research, vol. 59, no. 19, pp. 4870–4875, 1999.
- M. M. Gaudet, S. Chanock, J. Lissowska et al., “Comprehensive assessment of genetic variation of catechol-O- methyltransferase and breast cancer risk,” Cancer Research, vol. 66, no. 19, pp. 9781–9785, 2006.
- P. Boffetta, “Biomarkers in cancer epidemiology: an integrative approach,” Carcinogenesis, vol. 31, no. 1, pp. 121–126, 2009.
- T. Lotta, J. Vidgren, C. Tilgmann et al., “Kinetics of human soluble and membrane-bound catechol O- methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme,” Biochemistry, vol. 34, no. 13, pp. 4202–4210, 1995.
- H. M. Lachman, D. F. Papolos, T. Saito, Y. M. Yu, C. L. Szumlanski, and R. M. Weinshilboum, “Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders,” Pharmacogenetics, vol. 6, no. 3, pp. 243–250, 1996.
- E. Synowiec, J. Stefanska, Z. Morawiec, J. Blasiak, and K. Wozniak, “Association between DNA damage, DNA repair genes variability and clinical characteristics in breast cancer patients,” Mutation Research, vol. 648, no. 1-2, pp. 65–72, 2008.
- R. A. Santos, A. C. Teixeira, M. B. Mayorano, H. H. A. Carrara, J. M. Andrade, and C. S. Takahashi, “Basal levels of DNA damage detected by micronuclei and comet assays in untreated breast cancer patients and healthy women,” Clinical and Experimental Medicine, vol. 10, pp. 87–92, 2010.
- R. A. Santos, A. C. Teixeira, M. B. Mayorano, H. H. A. Carrara, J. M. Andrade, and C. S. Takahashi, “DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients,” Genetics and Molecular Biology, vol. 33, no. 4, pp. 637–640, 2010.
- S. Bonassi, A. Znaor, M. Ceppi et al., “An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans,” Carcinogenesis, vol. 28, no. 3, pp. 625–631, 2007.