Table 4: Estrogen-metabolizing gene polymorphisms in breast cancer patients and controls with frequency of micronucleated cells higher than the mean of each group.

GenotypeBreast cancer patients ( )Controls ( )OR (95% CI)P value
Number FrequencyNumberFrequency

CYP17
 TT120.4490.351.0 (reference).57
 TC+CC150.56170.650.6 (0.2–2.0)
CYP1B1
 Val/Val60.2230.121.0 (reference).46
 Val/Leu+Leu/Leu210.78230.880.46 (0.1–2.0)
CYP1A1
 TT210.78160.621.0 (reference).2
 TC+CC60.22100.380.4 (0.1–1.5)
COMT
 Val/Val60.22130.51.0 (reference).04
 Val/Met+Met/Met210.78130.53.5 (1–11.4)↑