Research Article

Approaching Biomarkers of Membranous Nephropathy from a Murine Model to Human Disease

Table 1

The 175 genes with significantly different expressions in the MN kidneys compared with the normal kidneys.

Increased expression

Adamts1: a disintegrin and metalloproteinase with thrombospondin motif type 1Ly6a: lymphocyte antigen 6 complex, locus A
Akr1b3: aldo-keto reductase family 1, B3Ly6e: lymphocyte antigen 6 complex,, locus E
Aldo: aldolase 1, A isoformLyzs: lysozyme
Anxa2: annexin A2Macs: myristoylated alanine rich protein
Anxa5: annexin A5Mglap: matrix gamma-carboxyglutamate (gla) protein
Arbp: acidic ribosomal phosphoproteinMorc3: MORC family CW-type zinc finger 3
Arpclb: actin-related proteinMpz: myelin protein zero
Axl: AXL receptor tyrosine kinaseMrgpre: MAS-related GPR, member E
Bgn: biglycanMrp63: mitochondrial ribosomal protein 63
C1ga: complement component C1gaMrps6: mitochondrial ribosomal protein S6
C1gc: complement component C1gcMt1: metallothionein 1
C3: complement component 3Mt2: metallothionein 2
Calbl: calbindin-28KMuc1: mucin 1, cell surface associated
Cap 1: adenylyl cyclase-associated protein 1Muc1: mucin 1, transmembrane
Capg: capping protein (actin filament)Nes: nestin
Cd24a: CD24a antigenNfkbia: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Cd9: CD9 antigenNid1: nidogen 1
Cldn7: claudin 7Npnt: nephronectin
Clic1: chloride intracellular channelPcolce: procollagen C-proteinase enhancer
Clu: clusterinPctp1: phosphatidylcholine transfer protein
Cmkbr2: chemokine (C-C) receptor 2Plat: plasminogen activator, tissue
Col 3a1: procollagen, type III, alpha 1Prdx6: peroxiredoxin 6
Col4a1: procollagen, type IV, alpha 1Prkab1: protein kinase, AMP-activated, beta 1 noncatalytic subunit
Col4a2: procollagen, type IV, alpha 2Ptma: prothymosin alpha
Colla2: procollagen, type I, alpha 2Rab31: member RAS oncogene family
Collal: procollagen, type I, alpha 1Raph1: Ras association and pleckstrin homology domains 1
Cox7a3: cytochrome c oxidase, subunit 7a3Rbm3: RNA binding motif protein 3
Csnkld: casein kinase 1 deltaRbm5: RNA binding motif protein 5
Csrp: cysteine rich proteinRhoc: ras homolog gene family, member C
Cst3: cystatin CRpia: ribose 5-phosphate isomerase A
Ctsc: cathepsin CRpl12: ribosomal protein L12
Ctsd: cathepsin DRpl29: ribosomal protein L29
Dbh: dopamine beta-hydroxylaseRpl3: ribosomal protein L3
Dgcr: DiGeorge syndrome critical regionRpl31: ribosomal protein L31
Dgk1: diacylglycerol kinase 1Rpl36: ribosomal protein L36
Dok7: docking protein 7Rpl37a: ribosomal protein L37a
Dppa2: developmental pluripotency associated 2Rpl41: ribosomal protein L41
Dtx1: deltex homolog 1 (Drosophila)Rpl5: ribosomal protein L5
Eef1a1: eukaryotic translation elongation factor 1 alpha 1Rpl7: ribosomal protein L7
Eif3d: eukaryotic translation initiation factor 3, subunit DRplp1: ribosomal protein, large, P1
Elk1: member of ETS oncogene familyRps15: ribosomal protein S15
Eras: ES cell expressed RasRps15: ribosomal protein S15
F2r: coagulation factor II (thrombin)Rps16: ribosomal protein S16
F9: coagulation factor IXRps20: ribosomal protein S20
Fau: Finkel-Biskis-Reilly murine sarcomaRps3a: ribosomal protein S3a
Fcerlg: Fc receptor, IgE high affinityRps4x: ribosomal protein S4, X-linked
Fkbp5: FK506 binding protein 5Rps6: ribosomal protein S6
Fn1: fibronectin 1Rrm2: ribonucleotide reductase M2
Fn14: fibroblast growth factor-inducible 14Rsbn1: round spermatid basic protein 1
Fstl: follistatin-like proteinRundc3a: RUN domain containing 3A
Ft11: ferritin light chain 1S100a6: S100 calcium binding protein A
Gnb211: guanine nucleotide binding proteinSam68: Src-associated in mitosis, 68kDa
Gpr56: G protein-coupled receptor 56Sdc4: syndecan 4
H2-Ebl: histocompatibility 2, class 1E betaSerpinb6: serpin peptidase inhibitor, B6
Hcfc1: host cell factor C1Serping1: serpin peptidase inhibitor, G1
Hdc-c: histidine decarboxylaseSerpinh1: serpin peptidase inhibitor, H1
Hmga1: high mobility group A1Sh3bgrl3: SH3 domain binding glutamic acid-rich protein like 3
Hmgb2: high mobility group box 2Sparc: secreted protein acidic and rich in cysteine
Hmgn2: high mobility group nucleosomal binding domain 2Spp1: secreted phosphoprotein 1
Hn1: hematological and neurological expressed protein 1Star: steroidogenic acute regulatory protein
Hnrp1: heterogeneous nuclear ribonucleoprotein A1Syn1: synapsin 1
Hsp25: heat shock protein, 25 kDaTbst1: protein-tyrosine sulfotransferase 1
Hsp84-1: heat shock protein, 84 kDa 1Tgfb1i4: transforming growth factor beta 1 induced transcript 4
Idb2: inhibitor of DNA binding 2Tip39: tuftelin-interacting protein 33
Klhl2: kelch-like 2, Mayven (Drosophila)Tmsb10: thymosin, beta 10
Krt2-8: keratin complex 2, basic, gene 8Tmsb4x: thymosin, beta 4, X chromosome
Lamr1: laminin receptor 1Tpi: triose phosphate isomerase
Laptm5: lysosomal associated protein multispanning transmembrane 5Tspan2: tetraspanin 2
Lcn2: lipocalin 2Tuba2: tubulin, alpha 2
Lcn7: lipocalin 7Tubb5: tubulin, beta 5
Ldh1: lactate dehydroaenase 1Ubc: ubiquitin C
Lgals3: lectin, galactoside-binding, soluble, 3Uchrb: Ubiquitin c-terminal hydrolase
Litaf: LPS-induced TNF-alpha factorUcp2: uncoupling protein 2
Lrat: lecithin retinol acyltransferaseWisp2: WNT1 inducible signaling pathway protein 2
Lu: Lutheran blood group glycoprotein

Decreased expression

Ak4: adenylate kinase 4Lrp2: low density lipoprotein receptor-related protein 2
Bhmt2: betaine-homocysteine methyltransferase 2Mad1l1: mitotic arrest deficient-like 1
Bid: BH3 interacting domain death agonistMap4: microtubule-associated protein 4
Ccnc: cyclin CMed28: mediator complex subunit 28
Cdc2a: cell division cycle 2 homolog AMegf10: multiple EGF-like-domains 10
Degs2: degenerative spermatocyte homolog 2Narg1: NMDA receptor regulated 1
Emp3: epithelial membrane protein 3Prlr: prolactin receptor
Ensa: endosulfine alphaRac GAP: Rac GTPase activating protein 1
Epha2: Eph receptor A2Rhd: Rh blood group, D antigen
Evi5: ecotropic viral integration site 5Rhov: ras homolog gene family, member V
Fignl1: fidgetin-like 1Slc15a2: solute carrier family 15, member 2
Hmgcs2: 3-hydroxy-3-methylglutaryl CoA synthase 2Ttr: Transthyretin
Hsd3b: 3-hydroxysteroid dehydrogenase type 2Xnp: X-linked nuclear protein