Table 1: Parameter values used to generate random numbers in computer simulations of a force response due to myosin crossbridges subjected to sinusoidal length perturbations, and estimated parameter values from that force response fit to (15). For all simulations , and = 1 pN/nm. Est = estimated value of bracketed parameter, indicates the ±95% confidence intervals for estimated value. The correlation between actual and estimated values resulted in a correlation coefficient greater than 0.997 for each parameter.

Sim numberpβ (ms) (ms) (pN/nm)Est Est[β] (ms)Est[ ] (ms)Est[ ] (pN/nm)

(1)1242440000.91 (0.01)25.13 (0.06)22.894005.0 (0.5)
(2)2122440002.01 (0.01)11.98 (0.03)24.094019.8 (0.4)
(3)382440003.22 (0.01)7.48 (0.02)24.083981.2 (0.4)
(4)642440006.11 (0.02)3.89 (0.01)23.793986.4 (0.4)
(5)832440008.70 (0.03)2.75 (0.01)23.953997.4 (0.4)
(6)42496100003.99 (0.01)24.03 (0.03)95.8810007.0 (0.3)
(7)81296100006.83 (0.01)13.93 (0.02)95.1210003.8 (0.3)
(8)128961000012.00 (0.02)7.98 (0.01)95.7110012.8 (0.3)
(9)166961000016.04 (0.03)6.05 (0.01)97.0310022.6 (0.3)
(10)244961000024.10 (0.06)3.99 (0.01)96.0710017.2 (0.3)
(11)482961000049.61 (0.15)1.92 (0.01)95.1310004.0 (0.3)

Note: .