Figure 1: p38 MAPK plays an essential role in the lupus nephritis in MRL- mice. (a) p38 MAPK inhibitor ameliorates kidney injury in MRL- mice. (b) The number of CD11c+ cells and CD11c+ CCR7+ mature phenotype was decreased by the inhibition of p38 MAPK in the kidney. (c) The transcripts of TNF-α were reduced by the administration of p38 MAPK inhibitor. ((d) and (e)) p38 MAPK is central for the production of IL-12 and IL-23 on DCs in MRL- mice.