Does Valproic Acid Induce Neuroendocrine Differentiation in Prostate Cancer?
Figure 1
Chromogranin A staining in prostate cancer cells treated with VPA in vitro. (a): Representative images of CgA staining for cell pellet sections from control and VPA-treated groups: LNCaP, C4-2, PC-3, and DU-145 (Scanned at 20X magnification using the APERIO imaging system). The tissue specimens of normal human prostate were positive internal controls for CgA staining. (b) Western blot analysis of cells treated in vitro. LNCaP, C4-2, DU-145, and PC-3 cells treated with VPA show induction of acetyl-H3, verifying HDACI activity, and downregulation of the NE marker CgA.
