Table 1: Characterization of amyloid accumulation in the mouse brain.

GenotypeAge (months)Number of plaques ( ) (counts/section)Insoluble fraction ( )Soluble fraction ( )
Aβ42 (ng/mg protein)Aβ40 (ng/mg protein)Aβ42 (pg/mg protein)Aβ40 (pg/mg protein)

wild-type2-3NDND ND
4-5NDND ND
6-7NDND ND

PS22-3NDND ND
4-5NDND ND
6-7NDND ND

Tg25762-3ND * ND
4-5ND * ND
6-7 *

PS2Tg25762-3 # *, #ND
4-5 # *, #
6-7 # *, # # *, #

The concentration of cerebral Aβ42 and Aβ40 in the TBS-insoluble and soluble fractions was measured with specific ELISA kits. Values represent the mean ± s.e.m. ND: not detectable. Statistical significance was assessed using the unpaired -test and Welch's test: * compared with the wild-type mice at the same age; # compared with the Tg2576 mice at the same age.