Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

Table 2

Comparison of AD-like phenotypes in transgenic mouse models.

Mouse model	Genetic background	Transgenes	Plaque onset*	Memory impair^#	Ref.
Tg2576	FVB/N	Prion promoted-APPswe (K670N, M671L)	7-8	6	[9, 12]
PS1Tg2576	Unknown	PDGF ^¶promoted-PS1 (M146L) × Prion promoted-APPswe	6	15-16	[13, 27]
PS2APP	B6D2F1	Prion promoted-PS2 (N141I) × thy1 promoted-APPswe	5	8	[28]
PS2Tg2576	B6 × 129S6	CAG^† promoted-PS2 (N141I)× Prion promoted-APPswe	2-3	4-5	This article

*Month of age. Previous reported onset of typical amyloid deposition. ^#Month of age. Previous reports of spatial learning and memory impairment in the Morris water maze. ^¶PDGF, platelet-derived growth factor promoter. ^†CAG, cytomegalovirus early enhancer coupled with chicken β-actin promoter.