Differential Effect of Calsequestrin Ablation on Structure and Function of Fast and Slow Skeletal Muscle Fibers

Table 1

Histological examination of adult Soleus fibers: fibers presenting structural damage were absent in WT, rare in CASQ1-null, but quite frequent in dCASQ-null. We classified abnormal fibers in two main classes: (a) fibers presenting large areas loosing cross striation, or unstructured cores, but no contractures (see Figure 4(f)); (b) fibers containing (also) contracture cores (see Figure 4(e), asterisk). (c) About 35% of Soleus fibers from dCASQ-null mice present severe structural alterations.

Soleus	Age (months)	Total no. of fibers analyzed	No. of fiber with alterations		(c) Total % of altered fiber
			(a) Unstructured cores	(b) Contracture cores
WT	5	29	—	—	—
	6	15	—	—	—
CASQ1-null	5	18	1 (6%)	—	6
	6.2	27	1 (4%)	—	4
					Average: 5%
dCASQ-null	4.8	25	7 (28%)	5 (20%)	48
	4.2	23	3 (13%)	4 (17%)	30
	4.8	47	2 (4%)	6 (13%)	17
	4.0	32	4 (13%)	9 (28%)	41
					Average: 34%