Histone Acetyltransferases as Regulators of Nonhistone Proteins: The Role of Interferon Regulatory Factor Acetylation on Gene Transcription
Figure 1
Two different functions of interferon regulatory factor-2 (IRF-2) through its acetylation by HAT. (a) During TPA-induced cell differentiation, IRF-2 binds histone acetylases, p300, and PCAF and inhibits core histone acetylation, resulting in the inhibition of IFN-inducible genes. (b) IRF-2 binds to PCAF and is acetylated. Acetylated IRF-2 is recruited to nuclear protein, nucleolin. The IRF-2/PCAF/nucleolin complex contributes to cell growth through the activation of ISRE-like site in the H4 gene promoter.
