Synergistic Effects between Phosphorylation of Phospholamban and Troponin I Promote Relaxation at Higher Heart Rate

Figure 3

Maximal rates of left ventricular pressure development and relaxation (±dP/dt_max) and time from peak to 75% relaxation (TR₇₅) of left ventricular pressure. (a) and (c) ±dP/dt_max and TR₇₅ under different rates of pacing. (b) and (d) ±dP/dt_max and TR₇₅ in different concentrations of ISO treatment. Data are mean ± SEM, 𝑛=6 hearts for each ISO concentration in each group. *𝑃<0.05 or **𝑃<0.01  versus baseline.

(a)

(b)

(c)

(d)