About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 680642, 12 pages
http://dx.doi.org/10.1155/2011/680642
Review Article

Animal Models of Bacterial Keratitis

Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA

Received 16 October 2010; Revised 29 November 2010; Accepted 9 December 2010

Academic Editor: Oreste Gualillo

Copyright © 2011 Mary E. Marquart. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bacterial keratitis is a disease of the cornea characterized by pain, redness, inflammation, and opacity. Common causes of this disease are Pseudomonas aeruginosa and Staphylococcus aureus. Animal models of keratitis have been used to elucidate both the bacterial factors and the host inflammatory response involved in the disease. Reviewed herein are animal models of bacterial keratitis and some of the key findings in the last several decades.