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Figure 4: Histopathological Mankin scores shown for distal radius articular cartilage of the reach limb in NC (normal control), NC + IBU (normal controls receiving ibuprofen for 8 weeks), TR (trained controls), TR + IBU (trained controls receiving ibuprofen treatment in final 8 weeks), HRHF (rats performing high-repetition high-force task for 12 weeks), and HRHF + IBU (HRHF rats receiving ibuprofen treatment in final 8 weeks). (a) Total scores for zones 2 and 3 are presented separately by group. (b) Mean of total scores for both zones 2 and 3. (c) Mankin score for structural changes in zone 2. (d) Mankin score for structural changes in zone 3. (e) Mankin score for cellular changes in zone 2. (f) Mankin score for cellular changes in zone 3. (g) Mankin score for staining changes in zone 2. (h) Mankin score for staining changes in zone 3. Abbreviations: 1 and 2 = and , respectively, compared to NC. 3 and 4 = and , respectively, compared to TR; 5 and 6 = and , respectively, compared to TR + IBU; 7 and 8 = and , respectively, compared to HRHF + IBU. 2* = when comparing zones 2 and 3 (zone 2 is higher). Statistical results compared to NC + IBU are not presented as they were comparable to NC results.