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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 715251, 9 pages
Preclinical Studies with Umbilical Cord Mesenchymal Stromal Cells in Different Animal Models for Muscular Dystrophy
1Human Genome Research Center, Biosciences Institute, University of Sao Paulo, Brazil
2Biotechnology Department, National Nuclear Energy Commission-IPEN-CNEN, Sao Paulo, Brazil
Received 29 March 2011; Revised 7 May 2011; Accepted 16 May 2011
Academic Editor: Ken-ichi Isobe
Copyright © 2011 Eder Zucconi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- P. A. Zuk, M. Zhu, H. Mizuno et al., “Multilineage cells from human adipose tissue: implications for cell-based therapies,” Tissue Engineering, vol. 7, no. 2, pp. 211–228, 2001.
- S. Gronthos, M. Mankani, J. Brahim, P. G. Robey, and S. Shi, “Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 25, pp. 13625–13630, 2000.
- M. Secco, E. Zucconi, N. M. Vieira et al., “Multipotent stem cells from umbilical cord: cord is richer than blood!,” Stem Cells, vol. 26, no. 1, pp. 146–150, 2008.
- T. Jazedje, P. M. Perin, C. E. Czeresnia et al., “Human fallopian tube: a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures,” Journal of Translational Medicine, vol. 7, article no. 46, 2009.
- M. Vainzof and M. Zatz, “Protein defects in neuromuscular diseases,” Brazilian Journal of Medical and Biological Research, vol. 36, no. 5, pp. 543–555, 2003.
- E. P. Hoffman, R. H. Brown Jr., and L. M. Kunkel, “Dystrophin: the protein product of the Duchenne muscular dystrophy locus,” Cell, vol. 51, no. 6, pp. 919–928, 1987.
- G. Bulfield, W. G. Siller, P. A. L. Wight, and K. J. Moore, “X chromosome-linked muscular dystrophy (mdx) in the mouse,” Proceedings of the National Academy of Sciences of the United States of America, vol. 81, no. 4, pp. 1189–1192, 1984.
- M. Vainzof, D. Ayub-Guerrieri, P. C. G. Onofre et al., “Animal models for genetic neuromuscular diseases,” Journal of Molecular Neuroscience, vol. 34, no. 3, pp. 241–248, 2008.
- N. J. H. Sharp, J. N. Kornegay, S. D. Van Camp et al., “An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophy,” Genomics, vol. 13, no. 1, pp. 115–121, 1992.
- E. Zucconi, M. C. Valadares, N. M. Vieira et al., “Ringo: discordance between the molecular and clinical manifestation in a golden retriever muscular dystrophy dog,” Neuromuscular Disorders, vol. 20, no. 1, pp. 64–70, 2010.
- M. Zatz, F. De Paula, A. Starling, and M. Vainzof, “The 10 autosomal recessive limb-girdle muscular dystrophies,” Neuromuscular Disorders, vol. 13, no. 7-8, pp. 532–544, 2003.
- J. C. Kaplan, “Gene table of monogenic neuromuscular disorders (nuclear genome only) Vol 19. No 1 January 2009,” Neuromuscular Disorders, vol. 19, no. 1, pp. 77–98, 2009.
- I. Mahjneh, M. R. Passos-Bueno, M. Zatz et al., “The phenotype of chromosome 2p-linked limb-girdle muscular dystrophy,” Neuromuscular Disorders, vol. 6, no. 6, pp. 483–490, 1996.
- J. Liu, M. Aoki, I. Illa et al., “Dysferlin, a novel skeletal muscle gene, is mutated in Miyoshi myopathy and limb girdle muscular dystrophy,” Nature Genetics, vol. 20, no. 1, pp. 31–36, 1998.
- C. Matsuda, M. Aoki, Y. K. Hayashi, M. F. Ho, K. Arahata, and R. H. Brown Jr., “Dysferlin is a surface membrane-associated protein that is absent in Miyoshi myopathy,” Neurology, vol. 53, no. 5, pp. 1119–1122, 1999.
- R. E. Bittner, L. V. B. Anderson, E. Burkhardt et al., “Dysferlin deletion in SJL mice (SJL-Dysf) defines a natural model for limb girdle muscular dystrophy 2B,” Nature Genetics, vol. 23, no. 2, pp. 141–142, 1999.
- E. Schultz and K. M. McCormick, “Skeletal muscle satellite cells,” Reviews of Physiology Biochemistry and Pharmacology, vol. 123, pp. 213–257, 1994.
- L. Heslop, J. E. Morgan, and T. A. Partridge, “Evidence for a myogenic stem cell that is exhausted in dystrophic muscle,” Journal of Cell Science, vol. 113, part 12, pp. 2299–2308, 2000.
- R. Laguens, “Satellite cells of skeletal muscle fibers in human progressive muscular dystrophy,” Virchows Archiv für Pathologische Anatomie und Physiologie und für Klinische Medizin, vol. 336, no. 6, pp. 564–569, 1963.
- M. Secco, E. Zucconi, N. M. Vieira et al., “Mesenchymal stem cells from umbilical cord: do not discard the cord!,” Neuromuscular Disorders, vol. 18, no. 1, pp. 17–18, 2008.
- E. Zucconi, N. M. Vieira, D. F. Bueno et al., “Mesenchymal stem cells derived from canine umbilical cord vein—a novel source for cell therapy studies,” Stem Cells and Development, vol. 19, no. 3, pp. 395–402, 2010.
- A. Can and S. Karahuseyinoglu, “Concise review: human umbilical cord stroma with regard to the source of fetus-derived stem cells,” Stem Cells, vol. 25, no. 11, pp. 2886–2895, 2007.
- P. S. Cho, D. J. Messina, E. L. Hirsh et al., “Immunogenicity of umbilical cord tissue-derived cells,” Blood, vol. 111, no. 1, pp. 430–438, 2008.
- K. Honeyman, K. S. Carville, J. M. Howell, S. Fletcher, and S. D. Wilton, “Development of a snapback method of single-strand conformation polymorphism analysis for genotyping golden retrievers for the X-linked muscular dystrophy allele,” American Journal of Veterinary Research, vol. 60, no. 6, pp. 734–737, 1999.
- J. L. Wagner, R. C. Burnett, S. A. Derose, L. V. Francisco, R. Store, and E. A. Ostrander, “Histocompatibility testing of dog families with highly polymorphic microsatellite markers,” Transplantation, vol. 62, no. 6, pp. 876–877, 1996.
- O. Pelz, M. Wu, T. Nikolova et al., “Duplex polymerase chain reaction quantification of human cells in a murine background,” Stem Cells, vol. 23, no. 6, pp. 828–833, 2005.
- M. Olivier, M. Breen, M. M. Binns, and G. Lust, “Localization and characterization of nucleotide sequences from the canine Y chromosome,” Chromosome Research, vol. 7, no. 3, pp. 223–233, 1999.
- M. Vainzof, M. R. Passos-Bueno, and M. Zatz, “Immunological methods for the analysis of protein expression in neuromuscular diseases,” Methods in Molecular Biology, vol. 217, pp. 355–378, 2003.
- P. F. Kennel, P. Fonteneau, E. Martin et al., “Electromyographical and motor performance studies in the pmn mouse model of neurodegenerative disease,” Neurobiology of Disease, vol. 3, no. 2, pp. 137–147, 1996.
- N. M. Vieira, E. Zucconi, C. R. Bueno Jr. et al., “Human multipotent mesenchymal stromal cells from distinct sources show different in vivo potential to differentiate into muscle cells when injected in dystrophic mice,” Stem Cell Reviews and Reports, vol. 6, no. 4, pp. 560–566, 2010.
- S. F. Phelps, M. A. Hauser, N. M. Cole et al., “Expression of full-length and truncated dystrophin mini-genes in transgenic mdx mice,” Human Molecular Genetics, vol. 4, no. 8, pp. 1251–1258, 1995.
- D. J. Wells, K. E. Wells, E. A. Asante et al., “Expression of human full-length and minidystrophin in transgenic mdx mice: implications for gene therapy of Duchenne muscular dystrophy,” Human Molecular Genetics, vol. 4, no. 8, pp. 1245–1250, 1995.
- M. Secco, Y. B. Moreira, E. Zucconi et al., “Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood,” Stem Cell Reviews and Reports, vol. 5, no. 4, pp. 387–401, 2009.
- T. Jazedje, M. Secco, N. M. Vieira et al., “Stem cells from umbilical cord blood do have myogenic potential, with and without differentiation induction in vitro,” Journal of Translational Medicine, vol. 7, article no. 6, 2009.
- E. J. Gang, J. A. Jeong, S. H. Hong et al., “Skeletal myogenic differentiation of mesenchymal stem cells isolated from human umbilical cord blood,” Stem Cells, vol. 22, no. 4, pp. 617–624, 2004.
- K. Y. Kong, J. Ren, M. Kraus, S. P. Finklestein, and R. H. Brown Jr., “Human umbilical cord blood cells differentiate into muscle in sjl muscular dystrophy mice,” Stem Cells, vol. 22, no. 6, pp. 981–993, 2004.
- P. B. Kang, H. G. W. Lidov, A. J. White et al., “Inefficient dystrophin expression after cord blood transplantation in duchenne muscular dystrophy,” Muscle and Nerve, vol. 41, no. 6, pp. 746–750, 2010.
- N. M. Vieira, C. R. Bueno Jr., V. Brandalise et al., “SJL dystrophic mice express a significant amount of human muscle proteins following systemic delivery of human adipose-derived stromal cells without immunosuppression,” Stem Cells, vol. 26, no. 9, pp. 2391–2398, 2008.
- M. Sampaolesi, S. Blot, G. D'Antona et al., “Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs,” Nature, vol. 444, no. 7119, pp. 574–579, 2006.
- C. Dell'Agnola, Z. Wang, R. Storb et al., “Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs,” Blood, vol. 104, no. 13, pp. 4311–4318, 2004.
- C. S. Kuhr, M. Lupu, and R. Storb, “Hematopoietic cell transplantation directly into dystrophic muscle fails to reconstitute satellite cells and myofibers,” Biology of Blood and Marrow Transplantation, vol. 13, no. 8, pp. 886–888, 2007.
- D. J. Prockop, “Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms,” Molecular Therapy, vol. 17, no. 6, pp. 939–946, 2009.
- K. English, A. French, and K. J. Wood, “Mesenchymal stromal cells: facilitators of successful transplantation?” Cell Stem Cell, vol. 7, no. 4, pp. 431–442, 2010.
- S. Tipnis, C. Viswanathan, and A. S. Majumdar, “Immunosuppressive properties of human umbilical cord-derived mesenchymal stem cells: role of B7-H1 and IDO,” Immunology and Cell Biology, vol. 88, no. 8, pp. 795–806, 2010.
- M. L. Weiss, C. Anderson, S. Medicetty et al., “Immune properties of human umbilical cord Wharton's jelly-derived cells,” Stem Cells, vol. 26, no. 11, pp. 2865–2874, 2008.
- L. Wang, L. Ott, K. Seshareddy, M. L. Weiss, and M. S. Detamore, “Musculoskeletal tissue engineering with human umbilical cord mesenchymal stromal cells,” Regenerative Medicine, vol. 6, no. 1, pp. 95–109, 2011.
- M. L. Weiss, K. E. Mitchell, J. E. Hix et al., “Transplantation of porcine umbilical cord matrix cells into the rat brain,” Experimental Neurology, vol. 182, no. 2, pp. 288–299, 2003.
- M. L. Weiss, S. Medicetty, A. R. Bledsoe et al., “Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease,” Stem Cells, vol. 24, no. 3, pp. 781–792, 2006.
- R. S. Rachakatla, F. Marini, M. L. Weiss, M. Tamura, and D. Troyer, “Development of human umbilical cord matrix stem cell-based gene therapy for experimental lung tumors,” Cancer Gene Therapy, vol. 14, no. 10, pp. 828–835, 2007.
- M. C. Pereira, M. Secco, D. E. Suzuki, et al., “Contamination of mesenchymal stem-cells with fibroblasts accelerates neurodegeneration in an experimental model of Parkinson's disease,” Stem Cell Reviews and Reports, 2011. In press.
- K. Chen, D. Wang, W. T. Du, et al., “Human umbilical cord mesenchymal stem cells hUC-MSC exert immunosuppressive activities through a PGE2 -dependent mechanism,” Clinical Immunology, vol. 135, no. 3, pp. 448–458, 2010.