Bioactive Food Components and Cancer-Specific Metabonomic Profiles

Table 2

Metabonomic profiles of metabolites from selected bioactive food components in human blood and urine.

Food source	Component	Metabonomic analysis	Blood	Urine	Reference
Green tea	EGCG	HPLC-MS/MS	EGCG	Sulfated and glucuronidated conjugates of EGCG, hippuric acids	Del Rio et al. [58] Wang JS et al. [59].
Soy	Genistein	LC-ESI-MS/MS	Monoglucuronides of genistein	Glucuronidated genistein	Guy et al. [60] Kano et al. [61].
Cruciferous vegetables	Glucobrassicin	HPLC-MS/MS	DIM, LTr1, H1-1M	DIM	Reed et al. [62] Anderton et al. [63].
Red grapes	Piceid	LC-MS/MS, NMR, HPLC/DAD	Sulfate and glucuronide conjugates of transresveratrol	Sulfate and glucuronide conjugates of trans-resveratrol	Burkon and Somoza [64]., Boocock et al. [65].
Cruciferous vegetables	Glucoraphanin	HPLC-MS, LC-(ESI)MS/MS	Sulforaphane	Mercapto-conjugates of sulforaphane (N-acetyl cysteine conjugates are major metabolites.)	Egner et al. [66], Al Janobi et al. [67].
Fish, Mushroom	Vitamin D2, D3	LC-MS/MS	25-OH vitamin D	24,25(OH)2D3, 1𝛼,24,25(OH)2D3	van den Ouweland et al. [68].