How the Virus Outsmarts the Host: Function and Structure of Cytomegalovirus MHC-I-Like Molecules in the Evasion of Natural Killer Cell Surveillance
Figure 3
X-ray structures of m157 (2NYK) [64], m153 (205N) [74, 84], m144 (IU58), HCMV UL18 (3D2U) [75], Tanapox 2L protein (3IT8) [85], and H-2Dd (3ECB) [86] reveal both shared and unique features. The disulfide bonds are in yellow. The α1, α2 and H2b helices and α3 domain are labeled. Ribbon diagrams of the structures in (a), rotated 90° to the right in (b), reveal differences in β2m and peptide binding (a, b). The view from the top shows differences in the peptide binding pocket (c). Illustrations were prepared from the superposed structures of the molecules using PyMOL http://www.pymol.org/.
