Quantifying Tumor Vascular Heterogeneity with Dynamic Contrast-Enhanced Magnetic Resonance Imaging: A Review
Figure 3
While the “onion-peeling” method has been demonstrated to be useful in animal xenografts, the specific assumption of radial heterogeneity may not apply to all in vivo human tumors. It can only be used on lesions with regular shape and a radial enhancement pattern (a). The lesion in (b) has an irregular, speculated shape that makes it difficult to define its center. Its enhancement pattern is also more stochastic, without a clear difference between the periphery and the tumor core. Applying the “onion-peeling” method to a tumor like this will not generate much useful information about the underlying tumor biology.
