Quantifying Tumor Vascular Heterogeneity with Dynamic Contrast-Enhanced Magnetic Resonance Imaging: A Review

Table 1

Pharmacokinetic parameters often used in DCE-MRI pharmacokinetic analysis.

Parameter	Definition	Units	Alternative names	Literature
𝐾^trans	Volume transfer constant between EES and blood plasma	min^−1	EF, 𝐾^PS	[22, 23, 26]
𝑣𝑒	EES volume per unit tissue volume	N/A	Interstitial space	[22, 23, 26]
𝑣𝑝	Blood plasma volume per unit tissue volume	N/A		[23]
𝑘𝑒𝑝	Rate constant from EES to blood plasma	min^−1	𝑘21	[22–26]
𝑘𝑝𝑒	Rate constant from blood plasma to EES	min^−1	𝑘12	[25]
𝑘el	Elimination rate constant	min^−1		[24, 25]
Amp	Amplitude of the normalized dynamic curve	N/A	A	[24, 25]