Bovine Model of Doxorubicin-Induced Cardiomyopathy

Figure 3

(a) Interstitial fibrosis as determined by Masson’s Trichrome staining in control and doxorubicin-treated hearts. (b) and (c) Representative histomicrographs of myocardial architecture in control and doxorubicin-treated hearts. In control animals, the outlines of individual myocytes are apparent. Interstitial endo- and perimysium are well established and clearly visible. In doxorubicin treated animals, normal myocyte borders are not apparent, and connective tissue is largely absent. 40x, white bar=50 μm, *𝑃<0.05 versus control. LV, left ventricle; RV, right ventricle; 𝑛=4/group.

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(b)

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