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Figure 4: mRNA expression for atrial natriuretic factor (ANF), connective tissue growth factor (CTGF), matrix metalloproteinase- (MMP-) 2, and MMP-9 in control and doxorubicin-treated hearts as quantified by real-time PCR. Individual gene expression was normalized to 18s ribosomal RNA and displayed as a percent of control. * versus control; /group.