About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 780836, 10 pages
http://dx.doi.org/10.1155/2011/780836
Research Article

Diagnosis and Prognostication of Ductal Adenocarcinomas of the Pancreas Based on Genome-Wide DNA Methylation Profiling by Bacterial Artificial Chromosome Array-Based Methylated CpG Island Amplification

1Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
2Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo 104-0045, Japan
3Cancer Genomics Project, National Cancer Center Research Institute, Tokyo 104-0045, Japan
4Proteome Bioinformatics Project, National Cancer Center Research Institute, Tokyo 104-0045, Japan
5Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
6Cancer Genome Center, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan

Received 22 July 2010; Accepted 12 November 2010

Academic Editor: Alain Filloux

Copyright © 2011 Masahiro Gotoh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. A. Jones and S. B. Baylin, “The fundamental role of epigenetic events in cancer,” Nature Reviews Genetics, vol. 3, no. 6, pp. 415–428, 2002. View at Scopus
  2. S. B. Baylin and J. E. Ohm, “Epigenetic gene silencing in cancer—a mechanism for early oncogenic pathway addiction?” Nature Reviews Cancer, vol. 6, no. 2, pp. 107–116, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. P. A. Jones and S. B. Baylin, “The epigenomics of cancer,” Cell, vol. 128, no. 4, pp. 683–692, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Ehrlich, “DNA hypomethylation in cancer cells,” Epigenomics, vol. 1, no. 2, pp. 239–259, 2009.
  5. S. Sharma, T. K. Kelly, and P. A. Jones, “Epigenetics in cancer,” Carcinogenesis, vol. 31, no. 1, pp. 27–36, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Kanai and S. Hirohashi, “Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state,” Carcinogenesis, vol. 28, no. 12, pp. 2434–2442, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Kanai, “Alterations of DNA methylation and clinicopathological diversity of human cancers,” Pathology International, vol. 58, no. 9, pp. 544–558, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Kanai, “Genome-wide DNA methylation profiles in precancerous conditions and cancers,” Cancer Science, vol. 101, no. 1, pp. 36–45, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. D. F. Peng, Y. Kanai, M. Sawada et al., “DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas,” Carcinogenesis, vol. 27, no. 6, pp. 1160–1168, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. D. F. Peng, Y. Kanai, M. Sawada et al., “Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas,” Cancer Science, vol. 96, no. 7, pp. 403–408, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Howes and J. P. Neoptolemos, “Risk of pancreatic ductal adenocarcinoma in chronic pancreatitis,” Gut, vol. 51, no. 6, pp. 765–766, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. R. H. Hruban, N. V. Adsay, J. Albores-Saavedra et al., “Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions,” American Journal of Surgical Pathology, vol. 25, no. 5, pp. 579–586, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Attri, R. Srinivasan, S. Majumdar, B. D. Radotra, and J. Wig, “Alterations of tumor suppressor gene p16 in pancreatic ductal carcinoma,” BMC Gastroenterology, vol. 5, article 22, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Xu, T. Furukawa, N. Kanai, M. Sunamura, and A. Horii, “Abrogation of DUSP6 by hypermethylation in human pancreatic cancer,” Journal of Human Genetics, vol. 50, no. 4, pp. 159–167, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Sato, H. Matsubayashi, N. Fukushima, and M. Goggins, “The chemokine receptor CXCR4 is regulated by DNA methylation in pancreatic cancer,” Cancer Biology and Therapy, vol. 4, no. 1, pp. 70–76, 2005. View at Scopus
  16. S. Nomoto, T. Kinoshita, T. Mori et al., “Adverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer,” British Journal of Cancer, vol. 98, no. 10, pp. 1690–1695, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. X. M. Bu, C. H. Zhao, N. Zhang, F. Gao, S. Lin, and X. W. Dai, “Hypermethylation and aberrant expression of secreted fizzled-related protein genes in pancreatic cancer,” World Journal of Gastroenterology, vol. 14, no. 21, pp. 3421–3424, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Omura, C. P. Li, A. Li et al., “Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma,” Cancer Biology and Therapy, vol. 7, no. 7, pp. 1146–1156, 2008. View at Scopus
  19. A. C. Tan, A. Jimeno, S. H. Lin et al., “Characterizing DNA methylation patterns in pancreatic cancer genome,” Molecular Oncology, vol. 3, no. 5-6, pp. 425–438, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Misawa, J. Inoue, Y. Sugino et al., “Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification,” Cancer Research, vol. 65, no. 22, pp. 10233–10242, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Sugino, A. Misawa, J. Inoue et al., “Epigenetic silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas,” Oncogene, vol. 26, no. 53, pp. 7401–7413, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Tanaka, I. Imoto, J. Inoue et al., “Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma,” Oncogene, vol. 26, no. 44, pp. 6456–6468, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Nishiyama, E. Arai, Y. Chihara et al., “Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage,” Cancer Science, vol. 101, no. 1, pp. 231–240, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Arai and Y. Kanai, “DNA methylation profiles in precancerous tissue and cancers: carcinogenetic risk estimation and prognostication based on DNA methylation status,” Epigenomics, vol. 2, no. 3, pp. 467–481, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Inazawa, J. Inoue, and I. Imoto, “Comparative genomic hybridization (CGH)-arrays pave the way for identification of novel cancer-related genes,” Cancer Science, vol. 95, no. 7, pp. 559–563, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Arai, S. Ushijima, H. Fujimoto et al., “Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome,” Carcinogenesis, vol. 30, no. 2, pp. 214–221, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. E. Arai, S. Ushijima, M. Gotoh et al., “Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma,” International Journal of Cancer, vol. 125, no. 12, pp. 2854–2862, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. S. B. Edge, D. R. Byrd, C. C. Compton, A. G. Fritz, F. L. Greene, and A. Trotti, Eds., Exocrine and Endocrine Pancreas, Springer, New York, NY, USA, AJCC Cancer Staging Manual Seventh edition, 2010.
  29. S. S. Han, J. Y. Jang, S. W. Kim, W. H. Kim, K. U. Lee, and Y. H. Park, “Analysis of long-term survivors after surgical resection for pancreatic cancer,” Pancreas, vol. 32, no. 3, pp. 271–275, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Schnelldorfer, A. L. Ware, M. G. Sarr et al., “Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible?” Annals of Surgery, vol. 247, no. 3, pp. 456–462, 2008. View at Scopus
  31. A. van den broeck, G. Sergeant, N. Ectors, W. van Steenbergen, R. Aerts, and B. Topal, “Patterns of recurrence after curative resection of pancreatic ductal adenocarcinoma,” European Journal of Surgical Oncology, vol. 35, no. 6, pp. 600–604, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Fatima, T. Schnelldorfer, J. Barton et al., “Pancreatoduodenectomy for ductal adenocarcinoma: implications of positive margin on survival,” Archives of Surgery, vol. 145, no. 2, pp. 167–172, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Shimada, Y. Sakamoto, S. Nara, M. Esaki, T. Kosuge, and N. Hiraoka, “Analysis of 5-year survivors after a macroscopic curative pancreatectomy for invasive ductal adenocarcinoma,” World Journal of Surgery, vol. 34, no. 8, pp. 1908–1915, 2010. View at Publisher · View at Google Scholar
  34. A. B. Lowenfels and P. Maisonneuve, “Epidemiology and prevention of pancreatic cancer,” Japanese Journal of Clinical Oncology, vol. 34, no. 5, pp. 238–244, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Loos, J. Kleeff, H. Friess, and M. W. Büchler, “Surgical treatment of pancreatic cancer,” Annals of the New York Academy of Sciences, vol. 1138, pp. 169–180, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. S. J. Clark, “Action at a distance: epigenetic silencing of large chromosomal regions in carcinogenesis,” Human Molecular Genetics, vol. 16, no. 1, pp. R88–R95, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. X. G. Ni, X. F. Bai, Y. L. Mao et al., “The clinical value of serum CEA, CA19-9, and CA242 in the diagnosis and prognosis of pancreatic cancer,” European Journal of Surgical Oncology, vol. 31, no. 2, pp. 164–169, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Ueno, T. Kosuge, Y. Matsuyama et al., “A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer,” British Journal of Cancer, vol. 101, no. 6, pp. 908–915, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. H. Ueno and T. Kosuge, “Adjuvant treatments for resectable pancreatic cancer,” Journal of Hepato-Biliary-Pancreatic Surgery, vol. 15, no. 5, pp. 468–472, 2008. View at Publisher · View at Google Scholar · View at Scopus