Review Article
Genetics, Cytogenetics, and Epigenetics of Colorectal Cancer
Table 1
Major CRC genes and syndromes.
| Gene(s) | Syndrome | Inheritance | Lifetime CRC risk |
| APC | FAP | Autosomal dominant | 100% | APC | AFAP | Autosomal dominant | 69% | MUTYH | MAP | Autosomal recessive | 80% | MLH1, MSH2, MSH6, PMS2, TACSTD1 (EpCAM) | LS | Autosomal dominant | 80% | STK11 | PJS | Autosomal dominant | 39% | SMAD4 (DPC4), BMPR1A | JPS | Autosomal dominant | 39% | PTEN | CS | Autosomal dominant | rare |
|
|