Review Article
Genetics, Cytogenetics, and Epigenetics of Colorectal Cancer
Table 2
Some of the genes or loci associated with CRC risk (see the text for details).
| Gene or locus | Type of study | Comment |
| GSTT1 | Meta-analysis of genetic association studies | GSTT1 null genotype associated with increased CRC risk (Caucasians) | GSTM1 | Meta-analysis of genetic association studies | GSTM1 null genotype associated with increased CRC risk (Caucasians) | COX2 | Meta-analysis of genetic association studies | Promoter polymorphisms associated with increased CRC risk (Asians) | MTHFR | Meta-analysis of genetic association studies | MTHFR 677C>T associated with increased CRC risk | NATs | Gene-environment interaction | Interaction between NATs polymorphisms and smoking status affect CRC risk | MTR | Meta-analysis of genetic association studies | MTR 2756A>G associated with increased CRC risk | SMAD7 | Genetic association studies and GWAS | SMAD7 variants associated with increased CRC risk | APC | Genetic association studies | APC I1307K associated with increased CRC risk in Ashkenazi Jews | IGF1 | Genetic association studies | IGF1 promoter polymorphisms associated with HNPCC age at onset | 8q23.3 | GWAS | Associated with CRC risk | 8q24 | GWAS | Associated with CRC risk | 10p14 | GWAS | Associated with CRC risk | 11q23 | GWAS | Associated with CRC risk | 15q13 | GWAS | Associated with CRC risk | 14q22.2 | Meta-analysis of GWAS | Associated with CRC risk | 16q22.1 | Meta-analysis of GWAS | Associated with CRC risk | 18q21 | GWAS | Associated with CRC risk | 19q13.1 | Meta-analysis of GWAS | Associated with CRC risk | 20p12.3 | Meta-analysis of GWAS | Associated with CRC risk |
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