Genetics, Cytogenetics, and Epigenetics of Colorectal Cancer

Table 2

Some of the genes or loci associated with CRC risk (see the text for details).

Gene or locus	Type of study	Comment
GSTT1	Meta-analysis of genetic association studies	GSTT1 null genotype associated with increased CRC risk (Caucasians)
GSTM1	Meta-analysis of genetic association studies	GSTM1 null genotype associated with increased CRC risk (Caucasians)
COX2	Meta-analysis of genetic association studies	Promoter polymorphisms associated with increased CRC risk (Asians)
MTHFR	Meta-analysis of genetic association studies	MTHFR 677C>T associated with increased CRC risk
NATs	Gene-environment interaction	Interaction between NATs polymorphisms and smoking status affect CRC risk
MTR	Meta-analysis of genetic association studies	MTR 2756A>G associated with increased CRC risk
SMAD7	Genetic association studies and GWAS	SMAD7 variants associated with increased CRC risk
APC	Genetic association studies	APC I1307K associated with increased CRC risk in Ashkenazi Jews
IGF1	Genetic association studies	IGF1 promoter polymorphisms associated with HNPCC age at onset
8q23.3	GWAS	Associated with CRC risk
8q24	GWAS	Associated with CRC risk
10p14	GWAS	Associated with CRC risk
11q23	GWAS	Associated with CRC risk
15q13	GWAS	Associated with CRC risk
14q22.2	Meta-analysis of GWAS	Associated with CRC risk
16q22.1	Meta-analysis of GWAS	Associated with CRC risk
18q21	GWAS	Associated with CRC risk
19q13.1	Meta-analysis of GWAS	Associated with CRC risk
20p12.3	Meta-analysis of GWAS	Associated with CRC risk