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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 797383, 15 pages
http://dx.doi.org/10.1155/2011/797383
Review Article

Experimental Trauma Models: An Update

Trauma Department, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany

Received 9 October 2010; Accepted 17 December 2010

Academic Editor: Monica Fedele

Copyright © 2011 Michael Frink et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Treatment of polytrauma patients remains a medical as well as socioeconomic challenge. Although diagnostics and therapy improved during the last decades, multiple injuries are still the major cause of fatalities in patients below 45 years of age. Organ dysfunction and organ failure are major complications in patients with major injuries and contribute to mortality during the clinical course. Profound understanding of the systemic pathophysiological response is crucial for innovative therapeutic approaches. Therefore, experimental studies in various animal models are necessary. This review is aimed at providing detailed information of common trauma models in small as well as in large animals.