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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 802581, 6 pages
http://dx.doi.org/10.1155/2011/802581
Research Article

Osteopontin Alleles Are Associated with Clinical Characteristics in Systemic Lupus Erythematosus

1Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, 5841 S. Maryland Avenue, MC0930, Chicago, IL 60637, USA
2Divison of Rheumatology and Rush Lupus Clinic, Rush University Medical Center, Chicago, IL 60612, USA

Received 29 July 2011; Accepted 20 August 2011

Academic Editor: George Tsokos

Copyright Β© 2011 Tarak Trivedi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Variants of the osteopontin (OPN) gene have been associated with systemic lupus erythematosus (SLE) susceptibility and cytokine profiles in SLE patients. It is not known whether these alleles are associated with specific clinical phenotypes in SLE. We studied 252 well-characterized SLE patients from a multiethnic cohort, genotyping the rs11730582, rs28357094, rs6532040, and rs9138 SNPs in the OPN gene. Ancestry informative markers were used to control for genetic ancestry. The SLE-risk allele rs9138C in the 3′ UTR region was associated with photosensitivity in lupus patients across all ancestral backgrounds (meta-analysis O R = 3 . 2 , 95% CI = 1.6–6.5, 𝑃 = 1 . 0 Γ— 1 0 βˆ’ 3 ). Additionally, the promoter variant rs11730582C demonstrated suggestive evidence for association with two hematologic traits: thrombocytopenia ( O R = 2 . 1 , 𝑃 = 0 . 0 2 3 ) and hemolytic anemia ( O R = 2 . 6 , 𝑃 = 0 . 0 3 6 ). These clinical associations with SNPs in the promoter and 3′ UTR regions align with previously reported SLE-susceptibility SNPs in OPN and suggest potential roles for these variants in antibody-mediated cytopenias and skin inflammation in SLE.