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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 802581, 6 pages
http://dx.doi.org/10.1155/2011/802581
Research Article

Osteopontin Alleles Are Associated with Clinical Characteristics in Systemic Lupus Erythematosus

1Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, 5841 S. Maryland Avenue, MC0930, Chicago, IL 60637, USA
2Divison of Rheumatology and Rush Lupus Clinic, Rush University Medical Center, Chicago, IL 60612, USA

Received 29 July 2011; Accepted 20 August 2011

Academic Editor: George Tsokos

Copyright © 2011 Tarak Trivedi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. E. Weckerle and T. B. Niewold, “The unexplained female predominance of systemic lupus erythematosus: clues from genetic and cytokine studies,” Clinical Reviews in Allergy and Immunology, vol. 40, no. 1, pp. 42–49, 2011.
  2. J. B. Harley, J. A. Kelly, and K. M. Kaufman, “Unraveling the genetics of systemic lupus erythematosus,” Springer Seminars in Immunopathology, vol. 28, no. 2, pp. 119–130, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Deapen, A. Escalante, L. Weinrib et al., “A revised estimate of twin concordance in systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 35, no. 3, pp. 311–318, 1992. View at Scopus
  4. J. E. Salmon, S. Millard, L. A. Schachter et al., “FcγRIIA alleles are heritable risk factors for lupus nephritis in African Americans,” Journal of Clinical Investigation, vol. 97, no. 5, pp. 1348–1354, 1996. View at Scopus
  5. E. F. Remmers, R. M. Plenge, A. T. Lee et al., “STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus,” The New England Journal of Medicine, vol. 357, no. 10, pp. 977–986, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. R. R. Graham, S. V. Kozyrev, E. C. Baechler et al., “A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus,” Nature Genetics, vol. 38, no. 5, pp. 550–555, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. J. B. Harley, M. E. Alarcon-Riquelme, L. A. Criswell et al., “Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci,” Nature Genetics, vol. 40, no. 2, pp. 204–210, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. S. N. Kariuki and T. B. Niewold, “Genetic regulation of serum cytokines in systemic lupus erythematosus,” Translational Research, vol. 155, no. 3, pp. 109–117, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Han, J. M. Guthridge, I. T. W. Harley et al., “Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction,” PLoS One, vol. 3, no. 3, Article ID e1757, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. S. D'Alfonso, N. Barizzone, M. Giordano et al., “Two single-nucleotide polymorphisms in the 5′ and 3′ ends of the osteopontin gene contribute to susceptibility to systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 52, no. 2, pp. 539–547, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. A. C. Forton, M. A. Petri, D. Goldman, and K. E. Sullivan, “An osteopontin (SPP1) polymorphism is associated with systemic lupus erythematosus,” Human Mutation, vol. 19, no. 4, p. 459, 2002. View at Scopus
  12. M. Scatena, L. Liaw, and C. M. Giachelli, “Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 11, pp. 2302–2309, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Masutani, M. Akahoshi, K. Tsuruya et al., “Predominance of Th1 immune response in diffuse proliferative lupus nephritis,” Arthritis and Rheumatism, vol. 44, no. 9, pp. 2097–2106, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Chabas, S. E. Baranzini, D. Mitchell et al., “The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease,” Science, vol. 294, no. 5547, pp. 1731–1735, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. C. K. Wong, L. C. W. Lit, L. S. Tam, E. K. Li, and C. W. K. Lam, “Elevation of plasma osteopontin concentration is correlated with disease activity in patients with systemic lupus erythematosus,” Rheumatology, vol. 44, no. 5, pp. 602–606, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. M. L. Shinohara, L. Lu, J. Bu et al., “Osteopontin expression is essential for interferon-α production by plasmacytoid dendritic cells,” Nature Immunology, vol. 7, no. 5, pp. 498–506, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. C. E. Weckerle, B. S. Franek, J. A. Kelly, et al., “Network analysis of associations between serum interferon-alpha activity, autoantibodies, and clinical features in systemic lupus erythematosus,” Arthritis & Rheumatism, vol. 63, no. 4, pp. 1044–1053, 2011.
  18. T. B. Niewold, D. N. Clark, R. Salloum, and B. D. Poole, “Interferon alpha in systemic lupus erythematosus,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 948364, 8 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. T. B. Niewold, J. Hua, T. J. A. Lehman, J. B. Harley, and M. K. Crow, “High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus,” Genes and Immunity, vol. 8, no. 6, pp. 492–502, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. S. N. Kariuki, J. G. Moore, K. A. Kirou, M. K. Crow, T. O. Utset, and T. B. Niewold, “Age- and gender-specific modulation of serum osteopontin and interferon-α by osteopontin genotype in systemic lupus erythematosus,” Genes and Immunity, vol. 10, no. 5, pp. 487–494, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Salloum and T. B. Niewold, “Interferon regulatory factors in human lupus pathogenesis,” Translational Research, vol. 157, no. 6, pp. 326–331, 2011.
  22. T. Robinson, S. N. Kariuki, B. S. Franek, et al., “Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-{alpha} and serologic autoimmunity in Lupus patients,” Journal of Immunology, vol. 187, no. 3, pp. 1298–1303, 2011.
  23. S. N. Kariuki, B. S. Franek, A. A. Kumar et al., “Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus,” Arthritis Research & Therapy, vol. 12, no. 4, p. R151, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. K. E. Taylor, E. F. Remmers, A. T. Lee et al., “Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus,” PLoS Genetics, vol. 4, no. 5, Article ID e1000084, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. I. T. W. Harley, T. B. Niewold, R. M. Stormont, et al., “The role of genetic variation near interferon-kappa in systemic lupus erythematosus,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 706825, 11 pages, 2010. View at Publisher · View at Google Scholar
  26. E. Sanchez, A. Nadig, B. C. Richardson, et al., “Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus,” Annals of the Rheumatic Diseases, vol. 70, no. 10, pp. 1752–1757, 2011.
  27. E. M. Tan, A. S. Cohen, J. F. Fries, et al., “The 1982 revised criteria for the classification of systemic lupus erythematosus,” Arthritis & Rheumatism, vol. 25, no. 11, pp. 1271–1277, 1982.
  28. S. N. Kariuki, B. S. Franek, R. A. Mikolaitis et al., “Promoter variant of PIK3C3 is associated with autoimmunity against Ro and Sm epitopes in African-American lupus patients,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 826434, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Kuwana, J. Kaburaki, Y. Okazaki, H. Miyazaki, and Y. Ikeda, “Two types of autoantibody-mediated thrombocytopenia in patients with systemic lupus erythematosus,” Rheumatology, vol. 45, no. 7, pp. 851–854, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. L. Ronnblom, M. L. Eloranta, and G. V. Alm, “Role of natural interferon-α producing cells (plasmacytoid dendritic cells) in autoimmunity,” Autoimmunity, vol. 36, no. 8, pp. 463–472, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. T. B. Niewold, “Interferon alpha as a primary pathogenic factor in human lupus,” Journal of Interferon & Cytokine Research. In press.
  32. L. Farkas, K. Beiske, F. Lund-Johansen, P. Brandtzaeg, and F. L. Jahnsen, “Plasmacytoid dendritic cells (natural interferon-α/β-producing cells) accumulate in cutaneous lupus erythematosus lesions,” The American Journal of Pathology, vol. 159, no. 1, pp. 237–243, 2001. View at Scopus