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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 806891, 8 pages
http://dx.doi.org/10.1155/2011/806891
Review Article

Mesenchymal Stem Cell-Based Tissue Engineering for Chondrogenesis

Department of Biotechnology, The Catholic University of Korea, Bucheon 420-743, Republic of Korea

Received 7 June 2011; Revised 19 July 2011; Accepted 12 August 2011

Academic Editor: Herman S. Cheung

Copyright © 2011 Seogjin Seo and Kun Na. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In tissue engineering fields, recent interest has been focused on stem cell therapy to replace or repair damaged or worn-out tissues due to congenital abnormalities, disease, or injury. In particular, the repair of articular cartilage degeneration by stem cell-based tissue engineering could be of enormous therapeutic and economic benefit for an aging population. Bone marrow-derived mesenchymal stem cells (MSCs) that can induce chondrogenic differentiation would provide an appropriate cell source to repair damaged cartilage tissues; however, we must first understand the optimal environmental conditions for chondrogenic differentiation. In this review, we will focus on identifying the best combination of MSCs and functional extracellular matrices that provides the most successful chondrogenesis.