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Figure 3: Schematic diagram of RGD-modified PLGA microspheres containing growth factors and dexamethasone. Using a layer-by-layer (LBL) technique, positively charged, PEI precoated PLGA microspheres coated with negatively charged RGD molecules were fabricated for hMSC delivery and regeneration of injured tissues. The combination of growth factors, DEX, and RGD was an effective scaffold for cell delivery and differentiation of embedded hMSCs [39].