Autophagic and Apoptotic Effects of HDAC Inhibitors on Cancer Cells

Table 3

Effects of HDAC inhibitor on the process of autophagy.

Mechanisms	HDAC inhibitors	Cell lines*	Detection methods	Ref
mTOR	SAHA	ESS-1	Phosphorylation (mTOR)	[33]
AIF	FK228	MRT	siRNA (AIF)	[34]
ROS	SAHA	K562, LAMA84	N-acetyl-cysteine, chloroquine	[35]
p21^CIP/WAF1	H40, SAHA	PC-3M, HL-60	mRNA, protein expression	[36]
HDAC1	FK228	HeLa	siRNA (HDAC1)	[37]
HDAC6	Tubacin	MEF	siRNA (HDAC6)	[38]
Mitochondria	LBH589, LAQ824	Eμ-myc lymphoma	Knockout (Apaf-1, caspase-9)	[39]

*ESS-1: endometrial stromal sarcoma cells; LAMA84: human chronic myeloid leukemia; MEF: mouse embryonic fibroblasts; MRT: malignant rhabdoid tumors.