Muscle Atrophy and Motor Neuron Degeneration in Human NEDL1 Transgenic Mice

Figure 3

Overexpression of hNEDL1 affected the hanging wire and foot print performances. (a) The hanging wire performance of wild-type (white bar: 𝑛=12) and hNEDL1-Tg mice (black bar: 𝑛=11) from the age of six to fifteen months. Data are mean ± SEM (^∗𝑃<.05; ^∗∗𝑃<.01). (b) The distance between forepaw/hindpaw placements in each stride was recorded and analyzed in the wild type (white bar: 𝑛=12) and hNEDL1-Tg mice (black bar: 𝑛=11) from the age of six to fifteen months. Data are mean ± SEM (^∗𝑃<.05; ^∗∗𝑃<.01).

(a)

(b)