Review Article

Manipulating Protein Acetylation in Breast Cancer: A Promising Approach in Combination with Hormonal Therapies?

Table 1

Expression of HDACs in relation with ER.

HDACHDAC expressionReferences

HDAC1Reduced expression from normal to DCIS (ER- tumors)[28]
Correlation with ER expression[29]
High level of mRNA in ER+ breast cancers[30]

HDAC2Locus deletion in ER+ PR+ breast cancers [31]
Underexpressed in ER+ breast cancers[3255]*

HDAC3Overexpressed in ER+ breast cancers [44]*
Correlation with ER expression [29]
Underexpressed in ER+ breast cancer [56]*

HDAC4Overexpressed in ER+ breast cancers [45, 47]*
Underexpressed in ER+ breast cancers[38, 43, 53, 54, 57]*

HDAC5Overexpressed in ER+ breast cancers[34, 37, 39, 51, 52, 54, 57, 58]*

HDAC6Overexpressed in ER+ breast cancers[45, 47, 51, 53]*
High level of mRNA in ER+ breast cancer[59]
Increased expression in ER+ breast cancer[60]
Underexpressed in ER+ breast cancers [32, 34, 37, 5052]*

HDAC7Overexpressed in ER+ breast cancers[3638, 40, 44, 45, 47, 53, 58, 61]*

HDAC8Underexpressed in ER+ breast cancers[45, 47, 56, 62]*

HDAC9Underexpressed in ER+ breast cancers[32, 34, 35, 3740, 45, 47, 5254, 58]*

HDAC10Overexpressed in ER+ ductal breast cancer [48]*

HDAC11Overexpressed in ER+ breast cancers[35, 3740, 43, 45, 47, 5153, 56, 58]*

SIRT1Overexpressed in ER+ breast cancers[38, 40, 46, 52, 53]*

References with * were obtained from the Oncomine database. Increased or decreased expression was considered statistically significant at .