Manipulating Protein Acetylation in Breast Cancer: A Promising Approach in Combination with Hormonal Therapies?

Table 3

HDACs and estrogen signaling.

HDAC	Effect on estrogen signaling	References
HDAC1	Recruited to the silenced ERα promoter	[80]
	Present on ER-target gene promoter region	[81]
	Knockdown reduces ERα levels	[82]
	Directly interact with ERα-suppresses ERα activity in 293T cells	[83]
HDAC2	Present on ER-target gene promoter region	[84]
	Knockdown reduces ERα levels	[82]
HDAC3	Present on ER-target gene promoter region	[81]
HDAC4	Present on ER-target gene promoter region	[85]
	Binds the N-terminal A/B domain of ERα	[86]
HDAC5	Repress ERα promoter via MEF2	[87]
	Directly interacts with ERα-Represses ERα activity
	KO associated with upregulation of ERα signaling
HDAC6	Knockdown reduces ERα levels	[82]
	Bind the AF2-domain of ERα	[88]
	Regulates ERα degradation via hsp90 acetylation	[89]
HDAC7	Present on the pS2 gene promoter region	[84]
	Represses ERα activity-Required for E2-dependent repression	[90]
HDAC9	Repress ERα promoter via MEF2	[87]
	Directly interacts with ERα-Represses ERα activity
	KO associated with upregulation of ERα signaling
SIRT1	Deacetylates ERαin vitro
	Knockdown reduces ERα levels	[91]