Androgen Receptor Signalling in Prostate Cancer: The Functional Consequences of Acetylation

Figure 1

Schematic representation of the human androgen receptor (AR). The N-terminal domain (NTD) contains activation function-1 (AF1), which is the major region important in transcriptional activation. The central DNA-binding domain (DBD) is coordinated by two zinc finger motifs and recognises specific androgen response elements. The ligand-binding domain (LBD), situated in the C-terminus, is structurally well characterised and contains the ligand-dependent transactivation domain, AF2. The flexible hinge region connects the structured DBD and LBD and contains both a nuclear localisation sequence and acetylation motif.