A Symphony of Regulations Centered on p63 to Control Development of Ectoderm-Derived Structures

Figure 1

Schematic representation of known and proposed p63 pathways relevant for epidermal differentiation, ectoderm-mesoderm signaling, and the onset of ectodermal dysplasias. p63, IKKα, and IRF6 play a role in the developing epidermis, in a cell autonomous way to facilitate cell cycle arrest and differentiation. The same molecules also regulate the expression of soluble factors such as TGFβ and members of the FGF family to regulate the development of the underlying mesoderm, via epithelial-mesenchymal signaling. Disease genes are framed in boxes; regulations/interactions are indicated with lines or arrows.