Table 2:
Characterization of the anticancer properties of hits. Cell viability assays were performed with hits from the assay, and IC
50
values were obtained for several nonsmall cell lung cancer cell lines and several melanoma cell lines (bold).
Drug ID
Cell Line
IC
50
(
μ
M)
NSC-22225/NSC-22206
H1395
>20
H1437
>10
H358
>10
Mel270
>
5
OCM3
>
5
NSC-150117
H1395
2.3
H1437
>10
H358
1.9
Mel270
1.7
OCM1
3.4
OCM3
2.2
Omm1
0.5
Omm2.3
1.7
NSC-693322
H1395
>10
H1437
>10
H358
8.7
Mel270
1.5
Mel285
1.7
OCM1
1.4
OCM3
2.9
Omm1
0.1
Omm2.3
0.3
NSC-159631
H1395
0.4
H1437
0.7
H358
0.6
HCC4018
0.4
Mel270
0.5
Mel285
0.8
OCM1
0.7
OCM3
0.3
Omm2.3
0.5