Table 2: Characterization of the anticancer properties of hits. Cell viability assays were performed with hits from the assay, and IC50 values were obtained for several nonsmall cell lung cancer cell lines and several melanoma cell lines (bold).

Drug IDCell LineIC50(μM)

NSC-22225/NSC-22206H1395>20
H1437>10
H358>10
Mel270>5
OCM3>5

NSC-150117H13952.3
H1437>10
H3581.9
Mel2701.7
OCM13.4
OCM32.2
Omm10.5
Omm2.31.7

NSC-693322H1395>10
H1437>10
H3588.7
Mel2701.5
Mel2851.7
OCM11.4
OCM32.9
Omm10.1
Omm2.30.3

NSC-159631H13950.4
H14370.7
H3580.6
HCC40180.4
Mel2700.5
Mel2850.8
OCM10.7
OCM30.3
Omm2.30.5