CYLD-mediated inhibition of HDAC6 leads to a delay in the cell cycle. CYLD binds acetylated microtubules and inhibits HDAC6. Inhibition of HDAC6 leads to increased levels of acetylated -tubulin and this induces more binding of CYLD to MTs. CYLD binds BCL-3, and in the presence of TPA blocks its nuclear translocation, thereby inhibiting cyclin-D1.
