Functions of MDMX in the Modulation of the p53-Response

Figure 1

Schematic representation of MDMX protein structure in comparison with MDM2. Most indicated protein modification sites and protein-protein interactions shown are discussed in the text. Modifications of MDMX by sumoylation (K254, K379) have not yet shown to affect function or regulation of MDMX [5]. Phosphorylation of S298 stimulates the association of MDMX to p53 [6], and phosphorylation of S96 has been reported to affect the regulation of subcellular localization of MDM2 [7].