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| SwissProt No. | Protein name | Protein function |
|
| O00160 | Myosin If | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements |
| O00339 | Matrilin-2 precursor | Involved in matrix assembly |
| O00459 | Phosphatidylinositol 3-kinase regulatory subunit β | Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. |
| O00469 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 precursor | Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links |
| O00623 | Peroxisome assembly protein 12 | Required for protein import into peroxisomes |
| O14686 | Myeloid/lymphoid or mixed-lineage leukemia protein 2 | Histone methyltransferase. Methylates “Lys-4” of histone H3. H3 “Lys-4” methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in β-globin locus transcription regulation by being recruited by NFE2. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription |
| O15020 | Spectrin β chain, brain 2 | Probably plays an important role in neuronal membrane skeleton |
| O15240 | Neurosecretory protein VGF precursor | May be involved in the regulation of cell-cell interactions or in synaptogenesis during the maturation of the nervous system |
| O15516 | Circadian locomotors output cycles protein kaput | ARNTL/2-CLOCK heterodimers activate E-box element (3′-CACGTG-5′) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression |
| O43395 | U4/U6 small nuclear ribonucleoprotein Prp3 | Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex |
| O43707 | α-actinin-4 | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein |
| O60242 | Brain-specific angiogenesis inhibitor 3 precursor | Might be involved in angiogenesis inhibition and suppression of glioblastoma |
| O60333 | Kinesin-like protein KIF1B | Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility |
| O75095 | Multiple epidermal growth factor-like domains 6 precursor | |
| O94851 | Protein MICAL-2 | |
| O94985 | Calsyntenin-1 precursor | Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of β-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by γ-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals |
| O95239 | Chromosome-associated kinesin KIF4A | Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization |
| O95248 | SET-binding factor 1 | Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is, however, sufficiently preserved to bind phosphorylated substrates, and may be protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts |
| O95271 | Tankyrase 1 | Regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the regulation of telomere length |
| O95274 | Ly6/PLAUR domain-containing protein 3 precursor | Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression |
| O95352 | Autophagy-related protein 7 | E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12 |
| P00390 | Glutathione reductase, mitochondrial precursor | Maintains high levels of reduced glutathione in the cytosol |
| P00441 | Superoxide dismutase (Cu-Zn) | Destroys radicals which are normally produced within the cells and which are toxic to biological systems |
| P00505 | Aspartate aminotransferase, mitochondrial precursor | Facilitates cellular uptake of long-chain free fatty acids |
| P01024 | Complement C3 precursor | C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability, and causes histamine release from mast cells and basophilic leukocytes |
| P01034 | Cystatin C precursor | As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity |
| P02452 | Collagen α-1(I) chain precursor | Type I collagen is a member of group I collagen (fibrillar forming collagen) |
| P02686 | Myelin basic protein | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The nonclassic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional posttranslational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation |
| P02751 | Fibronectin precursor | Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth |
| P02768 | Serum albumin precursor | Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin, and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood |
| P04075 | Fructose-bisphosphate aldolase A | |
| P04080 | Cystatin B | Intracellular thiol proteinase inhibitor |
| P04179 | Superoxide dismutase | Destroys radicals which are normally produced within the cells and which are toxic to biological systems |
| P06733 | α-enolase | Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance, and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. May be a tumor suppressor |
| P06744 | Glucose-6-phosphate isomerase | Neuroleukin is a neurotrophic factor for spinal and sensory neurons |
| P07195 | L-lactate dehydrogenase B chain | |
| P07737 | Profilin-1 | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG |
| P07814 | Bifunctional aminoacyl-tRNA synthetase | Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA |
| P07900 | Heat shock protein HSP 90-α | Molecular chaperone. Has ATPase activity |
| P07996 | Thrombospondin-1 precursor | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin, type V collagen, and integrins α-V/ β-1, α-V/ β-3 and α-IIb/ β-3 |
| P08238 | Heat shock protein HSP 90- β | Molecular chaperone. Has ATPase activity. |
| P09104 | γ-enolase | Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival |
| P09382 | Galectin-1 | Cell apoptosis and cell differentiation |
| P09486 | SPARC precursor | Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity |
| P09493 | Tropomyosin 1 α chain | Binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments |
| P09622 | Dihydrolipoyl dehydrogenase, mitochondrial precursor | Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the α-ketoacid dehydrogenase complexes |
| P09972 | Fructose-bisphosphate aldolase C | |
| P10071 | Zinc finger protein GLI3 | A role in limb and brain development |
| P10599 | Thioredoxin | Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions |
| P10909 | Clusterin precursor | Not yet clear. It is known to be expressed in a variety of tissues, and it seems to be able to bind to cells, membranes, and hydrophobic proteins. It has been associated with programmed cell death (apoptosis) |
| P11047 | Laminin γ-1 chain precursor | Binding to cells via a high-affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components |
| P11117 | Lysosomal acid phosphatase precursor | |
| P12814 | α-actinin-1 | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein |
| P13569 | Cystic fibrosis transmembrane conductance regulator | Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter |
| P13929 | β-enolase | Appears to have a function in striated muscle development and regeneration |
| P14136 | Glial fibrillary acidic protein, astrocyte | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells |
| P14174 | Macrophage migration inhibitory factor | Mediator in regulating the function of macrophage in host defense |
| P14618 | Pyruvate kinase isozymes M1/M2 | Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP |
| P15531 | Nucleoside diphosphate kinase A | Synthesis of nucleoside triphosphates other than ATP |
| P16035 | Metalloproteinase inhibitor 2 precursor | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16, and MMP-19 |
| P17612 | cAMP-dependent protein kinase, α-catalytic subunit | Phosphorylates a large number of substrates in the cytoplasm and the nucleus |
| P18669 | Phosphoglycerate mutase 1 | Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of synthase and phosphatase, but with a reduced activity |
| P23528 | Cofilin-1 | Controls reversibly actin polymerization and depolymerization |
| P26232 | α-2 catenin | |
| P27797 | Calreticulin precursor | Molecular calcium binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export |
| P29400 | Collagen α-5(IV) chain precursor | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a “chicken-wire” meshwork together with laminins, proteoglycans and entactin/nidogen |
| P29401 | Transketolase | |
| P30086 | Phosphatidylethanolamine-binding protein 1 | Binds ATP, opioids, and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin, and chymotrypsin but not trypsin, tissue type plasminogen activator, and elastase/HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor |
| P30154 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A β isoform | The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit |
| P34932 | Heat shock 70 kDa protein 4 | |
| P35442 | Thrombospondin-2 precursor | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin, and type V collagen |
| P35573 | Glycogen debranching enzyme | Multifunctional enzyme acting as 1,4-α-D-glucan:1,4-α-D-glucan 4-α-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation |
| P35609 | α-actinin-2 | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein |
| P35711 | Transcription factor SOX-5 | Binds specifically to the DNA sequence 5′-AACAAT-3′. Activates transcription of COL2A1 and AGC1 in vitro |
| P37268 | Squalene synthetase | |
| P39191 | Alu subfamily SB2 sequence contamination warning entry | |
| P40925 | Malate dehydrogenase, cytoplasmic | |
| P46940 | Ras GTPase-activating-like protein IQGAP1 | Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth |
| P49746 | Thrombospondin-3 precursor | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin, and type V collagen |
| P50395 | Rab GDP dissociation inhibitor β | Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them |
| P53618 | Coatomer subunit β | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi nonclathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors |
| P58546 | Myotrophin | Cerebellar morphogenesis |
| P59998 | Actin-related protein 2/3 complex subunit 4 | Actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks |
| P60174 | Triosephosphate isomerase | |
| P62937 | Peptidyl-prolyl cis-trans isomerase A | PPIases accelerate the folding of proteins |
| P63104 | 14-3-3 protein zeta/delta | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner |
| P78527 | DNA-dependent protein kinase catalytic subunit | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence (ST)-Q. Phosphorylates “Ser-139” of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, c-myc/MYC, and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate TP53/p53 in the presence of supercoiled DNA is dependent on C1D |
| P81274 | G-protein signaling modulator 2 | Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) α proteins. Acts to stabilize the apical complex during neuroblast divisions |
| P81605 | Dermcidin precursor | DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E. coli, E. faecalis, S. aureus and C. albicans. Optimal pH and salt concentration resemble the conditions in sweat. Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG |
| P82279 | Crumbs homolog 1 precursor | Photoreceptor morphogenesis in the retina/May maintain cell polarization and adhesion |
| Q04760 | Lactoylglutathione lyase | Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione |
| Q06495 | Sodium-dependent phosphate transport protein 2A | May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70–80% of the apical influx |
| Q06830 | Peroxiredoxin-1 | Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-α by regulating the intracellular concentrations of H2O2 |
| Q08378 | Golgin subfamily A member 3 | Golgi autoantigen; probably involved in maintaining Golgi structure |
| Q08380 | Galectin-3-binding protein precursor | Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells |
| Q12799 | T-complex protein 10A homolog | |
| Q12841 | Follistatin-related protein 1 precursor | May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin |
| Q13045 | Protein flightless-1 homolog | May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration |
| Q13075 | Baculoviral IAP repeat-containing protein 1 | Prevents motor-neuron apoptosis induced by a variety of signals |
| Q13136 | Liprin-α-1 | Regulate the disassembly of focal adhesions/may localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates |
| Q13371 | Phosducin-like protein | |
| Q13740 | CD166 antigen precursor | Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system |
| Q14980 | Nuclear mitotic apparatus protein 1 | May be a structural component of the nucleus |
| Q15084 | Protein disulfide-isomerase A6 precursor | Catalyzes the rearrangement of -S-S- bonds in proteins |
| Q15113 | Procollagen C-endopeptidase enhancer 1 precursor | Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity |
| Q32MQ0 | Protein ZNF750 | |
| Q5VTR2 | Ubiquitin-protein ligase BRE1A | E3 ubiquitin-protein ligase that mediates monoubiquitination of “Lys-120” of histone H2B. H2B “Lys-120” ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 “Lys-4” and “Lys-79” methylation. Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBE2E1/UBCH6. It thereby plays a central role in histone code and gene regulation. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator |
| Q6KC79 | Nipped-B-like protein | Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex |
| Q6NUM9 | All-trans-retinol 13,14-reductase precursor | Play a role in the metabolism of vitamin A |
| Q6ZU80 | Protein C14orf145 | |
| Q6ZUB1 | Protein C9orf79 | |
| Q7L1I2 | Synaptic vesicle glycoprotein 2B | Probably plays a role in the control of regulated secretion in neural and endocrine cells |
| Q7Z3E2 | Protein C10orf118 | |
| Q8IWJ2 | GRIP and coiled-coil domain-containing protein 2 | Function probably involved in maintaining Golgi structure |
| Q8N0X7 | Spartin | May be implicated in endosomal trafficking, or microtubule dynamics, or both. |
| Q8N1I0 | Dedicator of cytokinesis protein 4 | Involved in regulation of adherens junction between cells. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP |
| Q8TEU7 | Rap guanine nucleotide exchange factor 6 | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A, and M-Ras GTPases. Does not interact with cAMP |
| Q8TF76 | Serine/threonine-protein kinase Haspin | Required for normal alignment of chromosomes at metaphase. Phosphorylates histone H3 “Thr-3” during mitosis |
| Q8WUT4 | Uncharacterized protein C20orf75 precursor | May play an important role in hippocampus-dependent long-lasting memory |
| Q96EZ8 | Microspherule protein 1 | Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. May be an inhibitor of TERT telomerase activity |
| Q96Q42 | Alsin | May act as a GTPase regulator. Controls survival and growth of spinal motoneurons |
| Q9BXM0 | Periaxin | Is required for maintenance of peripheral nerve myelin sheath/may have a role in axon-glial interactions |
| Q9NVP4 | Protein C20orf12 | |
| Q9NX63 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 3 | |
| Q9P0K1 | ADAM 22 precursor | Probable ligand for integrin in the brain. This is a noncatalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation |
| Q9UM47 | Neurogenic locus notch homolog protein 3 precursor | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-Jκ and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation, and apoptotic programs |
| Q9UM54 | Myosin-6 | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent prosurvival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells |
| Q9UPQ9 | Trinucleotide repeat-containing 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins |
| Q9UPT6 | C-jun-amino-terminal kinase-interacting protein 3 | Mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins |
| Q9UQ26 | Regulating synaptic membrane exocytosis protein 2 | Rab effector involved in exocytosis. May act as scaffold protein. |
| Q9Y333 | U6 snRNA-associated Sm-like protein LSm2 | Binds specifically to the 3′-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing |
| Q9Y587 | AP-4 complex subunit sigma-1 | Subunit of novel type of clathrin- or nonclathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system |
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