Review Article
Atherosclerosis and Thrombosis: Insights from Large Animal Models
Table 2
Different animal models in order to evaluate thrombus formation.
| Reference | Method applied in order to induce plaque rupture and/or thrombus formation | Animal model |
| Reddick et al. [99] | Forceps squeezing of the aorta | Apo E-/- mice | Gertz et al. [100] Rekhter et al. [101] | Combination of double ballon injury and hypercholesterolemia and further angioplasty-induced plaque rupture | Rabbits | Eitzman et al. [102] | Photochemical reaction to previously formed atherosclerotic plaques | Apo E-/- mice | Constantinides et al. [103] Abela et al. [104] Nakamura et al. [105] | Intraperitoneal injection of Russell’s viper venom* followed by i.v. injection of histamine (vasopressor), serotonin or angiotensin II | Hypercholesterolemic rabbits | Rekhter et al. [106] | Intracerebroventricular injection of corticotrophin-releasing factors (“stress hormone”) | Apo E-/- mice | Heras et al. [107] | Carotid angioplasty | Pig | Badimon et al. [52, 108] Lassila et al. [65] | Thrombogenic effect of shear stress and atherosclerotic vessel components on the extracorporeal perfusion system | Pig | Badimon et al. [36] Fuster et al. [109, 110] | Von Willebrand factor deficiency | Pigs with von Willebrand disease |
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*Procoagulant and endothelial toxin.
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