Quantitative Proteomics Analysis by Isobaric Tags for Relative and Absolute Quantitation Identified Lumican as a Potential Marker for Acute Aortic Dissection
Table 3
List of the decreased (<0.5 folds) protein targets identified and their corresponding class, associated biological process, and cellular component.
N
Unuseda
Peptidesb
Accession #
Name
Biological process
Cellular component
Protein classification
AAD/CON ratio
AAD/AMI ratio
1
19.31
17
P02775
Platelet basic protein
Blood coagulation
Transfer/carrier protein
0.0209
0.0398
2
44.6
31
P02671
Fibrinogen alpha chain
Blood coagulation
Extracellular matrix
Transfer/carrier protein
0.0370
0.0203
3
19.82
30
P02656
Apolipoprotein C-III
Lipid metabolic process
Transporter
0.0570
0.0240
4
5.7
5
P01717
Ig lambda chain V-IV region Hil
Unclassified
0.0655
0.0679
5
8.45
4
P02768
Serum albumin
Transport
Transfer/carrier protein
0.0724
0.8472
6
3.22
1
P04264
Keratin, type II cytoskeletal 1
Cellular component morphogenesis
Cytoskelelton
Structural protein
0.0780
0.9639
7
2.05
1
P04070
Vitamin K-dependent protein C
Blood coagulation
Protease
0.0794
0.0441
8
34.98
27
P02652
Apolipoprotein A-II
Lipid metabolic process
Transporter
0.0991
0.1067
9
20.3
10
P02654
Apolipoprotein C-I
Lipid metabolic process
Transporter
0.1159
0.0847
10
94.94
108
P02765
Alpha-2-HS-glycoprotein
Protein metabolic process
Extracellular matrix
Extracellular matrix protein
0.1180
0.1472
11
39.07
25
P01008
Antithrombin-III
Protein metabolic process
Enzyme modulator
0.1202
0.0973
12
72.69
57
P00734
Prothrombin
Blood coagulation
Enzyme modulator
0.1225
0.2051
13
6.88
3
P27918
Properdin
Response to stimulus
Unclassified
0.1419
0.1905
14
6.31
4
P69905
Hemoglobin subunit alpha
Blood circulation
Transfer/carrier protein
0.1500
0.2312
15
8.97
15
Q03591
Complement factor H-related protein 1
Blood coagulation
Transfer/carrier protein
0.1706
0.0991
16
27.03
22
P10909
Clusterin
Apoptosis
Unclassified
0.1905
0.1076
17
2
1
Q15942
Zyxin
Cellular component morphogenesis
Enzyme modulator
0.1923
0.2109
18
20.4
26
P01024
Complement C3
Protein metabolic process
Transfer/carrier protein
0.2070
0.1406
19
7.43
3
P17936
Insulin-like growth factor-binding protein 3
Cell-matrix adhesion
Unclassified
0.2089
0.3162
20
2.23
2
P55290
Cadherin-13
Cell-cell adhesion
Cell junction
Receptor
0.2188
0.1660
21
1.41
1
P13598
Intercellular adhesion molecule 2
Cell-cell adhesion
Transfer/carrier protein
0.2355
0.1600
22
96.24
64
P00751
Complement factor B
Blood coagulation
Transfer/carrier protein
0.2466
0.2729
23
28.82
16
P09871
Complement C1s subcomponent
Blood coagulation
Protease
0.2606
0.4169
24
13.74
9
P01019
Angiotensinogen
Protein metabolic process
Enzyme modulator
0.2630
0.5058
25
95.34
74
P19823
Inter-alpha-trypsin inhibitor heavy chain H2
Protein metabolic process
Enzyme modulator
0.2805
0.5649
26
5.15
2
P18065
Insulin-like growth factor-binding protein 2
Cell-matrix adhesion
Unclassified
0.2884
0.3281
27
16.84
10
P07996
Thrombospondin-1
Blood coagulation
Extracellular matrix
Transfer/carrier protein
0.3404
0.8317
28
5.31
3
P26927
Hepatocyte growth factor-like protein
Blood coagulation
Transfer/carrier protein
0.3436
0.3436
29
7.85
4
O14791
Apolipoprotein L1
Lipid metabolic process
Transporter
0.3908
0.2831
30
94.76
57
P06727
Apolipoprotein A-IV
Lipid metabolic process
Transporter
0.4018
0.1837
31
14.1
9
P35527
Keratin, type I cytoskeletal 9
Cellular component morphogenesis
Structural protein
0.4055
0.7244
32
9.48
6
P00746
Complement factor D
Blood coagulation
Protease
0.4571
0.6668
33
48.09
24
P02649
Apolipoprotein E
Lipid metabolic process
Transporter
0.4656
0.2051
34
38.8
32
P02735
Serum amyloid A protein
Immune system process
Transporter
0.4742
0.0319
35
9.46
5
P10720
Platelet factor 4 variant
Blood coagulation
Transfer/carrier protein
0.4742
0.5105
36
53.31
29
P02774
Vitamin D-binding protein
Transport
Transfer/carrier protein
0.4831
2.2287
a Unused > 1.3 means at least 95% confidence; bnumber of peptides with 95% confidence; AAD: acute aortic dissection; AMI: acute myocardial infarction; CON: normal control.
