Intravesical Dimethyl Sulfoxide Inhibits Acute and Chronic Bladder Inflammation in Transgenic Experimental Autoimmune Cystitis Models
Figure 2
Intravesical DMSO treatment reduces bladder histopathology in acute autoimmune cystitis. Acute cystitis was induced and treated in URO-OVA mice as shown in Figure 1. At day 10, the bladders were collected, prepared for histological cross-sections, and stained with H&E solution. (a) The normal bladder showing unremarkable mucosa and muscularis. (b) The PBS-treated bladder showing remarkable cellular infiltration, interstitial edema, and mucosal hyperemia in the lamina propria. (c) The DMSO-treated bladder showing scattered cellular infiltration and minimum edema and hyperemia. The slides are representative of 5 bladders in each group. Magnification: for the left pane and for the right panel.
