Cervicovaginal Safety of the Formulated, Biguanide-Based Human Immunodeficiency Virus Type 1 (HIV-1) Inhibitor NB325 in a Murine Model

Figure 1

Exposure to saline results in no damage to the cervicovaginal epithelia. Mice were exposed to saline and sacrificed at 10 min, 2 h, 4 h, or 8 h after application. H&E-stained vaginal (a) and cervical (b) epithelial tissues were analyzed for damage. Representative micrograph fields from the 2 h exposure are shown. Images are representative of three mice per exposure duration.