Cervicovaginal Safety of the Formulated, Biguanide-Based Human Immunodeficiency Virus Type 1 (HIV-1) Inhibitor NB325 in a Murine Model

Figure 6

Short exposures to NB325 formulated at 1% result in mild vaginal epithelial toxicity. Mice were exposed to 1% formulated NB325 for 10 min, 2 h, or 4 h prior to sacrifice and isolation of reproductive tract tissues. H&E-stained tissue sections were analyzed for toxicity to the vaginal ((a), (c), (e)) and cervical ((b), (d), (f)) epithelia. Representative micrograph fields for each exposure are shown. Images are representative of three mice per exposure duration.